Kuikka J T, Bergström K A, Ahonen A, Hiltunen J, Haukka J, Länsimies E, Wang S, Neumeyer J L
Department of Clinical Physiology, Kuopio University Hospital, Finland.
Eur J Nucl Med. 1995 Apr;22(4):356-60. doi: 10.1007/BF00941854.
Several cocaine congeners are of potential for imaging the dopamine transporter (DAT). Previous studies have shown that iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I] beta-CIT) is a promising radiotracer for imaging the serotonin (5-HT) and dopamine (DA) transporters in the living human brain with single-photon emission tomography (SPET). [123I] beta-CIT was found to be not very practical for 1-day DAT imaging protocols since peak DAT uptake occurs later than 8 h. Here we report a pilot comparison of [123I] beta-CIT and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane ([123I] beta-CIT-FP), using SPET imaging in four healthy male subjects. Peak uptake of [123I] beta-CIT-FP into the basal ganglia occurred earlier (3-4 h after injection of tracer) than that of [123I] beta-CIT (> 8 h). However, the specific DAT binding of [123I] beta-CIT-FP in the basal ganglia was somewhat less (0.813 +/- 0.047) than that of [123I] beta-CIT (0.922 +/- 0.004). Imaging quality is excellent with both tracers and they are potentially of value for brain imaging in various neuropsychiatric disorders.
几种可卡因同系物具有用于多巴胺转运体（DAT）成像的潜力。先前的研究表明，碘-123标记的2β-甲氧羰基-3β-（4-碘苯基）托烷（[123I]β-CIT）是一种很有前景的放射性示踪剂，可用于通过单光子发射断层扫描（SPET）对活体人脑中的5-羟色胺（5-HT）和多巴胺（DA）转运体进行成像。[123I]β-CIT被发现对于1日DAT成像方案不太实用，因为DAT摄取峰值出现在8小时之后。在此我们报告了在四名健康男性受试者中使用SPET成像对[123I]β-CIT和2β-甲氧羰基-3β-（4-碘苯基）-N-（3-氟丙基）去甲托烷（[123I]β-CIT-FP）进行的初步比较。[123I]β-CIT-FP在基底神经节中的摄取峰值出现得比[123I]β-CIT更早（注射示踪剂后3 - 4小时）（> 8小时）。然而，[123I]β-CIT-FP在基底神经节中的特异性DAT结合略低于[123I]β-CIT（0.813±0.047）（0.922±0.004）。两种示踪剂的成像质量都很好，它们在各种神经精神疾病的脑成像中可能具有价值。
