Leroy D, Dompmartin A, Szczurko C, Michel M, Louvet S
Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France.
Photodermatol Photoimmunol Photomed. 1997 Jun;13(3):93-7. doi: 10.1111/j.1600-0781.1997.tb00123.x.
The aim of this study was to evaluate the possibility of cross-reactivity between ketoprofen, fenofibrate and benzophenones because of their structural similarities. Seven patients presenting photodermatitis from ketoprofen underwent patch and photopatch tests. Ketoprofen, fenofibrate, benzophenone 3, benzophenone 10, benzophenone 4, personal medications and topical creams were tested. All patients had positive patch or photopatch tests to ketoprofen and fenofibrate, four patients had positive UVA photopatch tests to benzophenone 3, and two to benzophenone 10. Patients presenting photosensitization to ketoprofen may also have cross-reactivity to fenofibrate and some benzophenones.
本研究的目的是评估酮洛芬、非诺贝特和二苯甲酮之间由于结构相似而发生交叉反应的可能性。7例因酮洛芬出现光皮炎的患者接受了斑贴试验和光斑贴试验。对酮洛芬、非诺贝特、二苯甲酮3、二苯甲酮10、二苯甲酮4、个人用药和外用乳膏进行了检测。所有患者对酮洛芬和非诺贝特的斑贴试验或光斑贴试验均呈阳性，4例患者对二苯甲酮3的UVA光斑贴试验呈阳性，2例对二苯甲酮10呈阳性。对酮洛芬出现光敏反应的患者可能也会对非诺贝特和某些二苯甲酮产生交叉反应。
