Sugita Y, Masuho Y
Molecular Medicine Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd. Tsukuba, Japan.
Immunotechnology. 1995 Dec;1(3-4):157-68. doi: 10.1016/1380-2933(95)00018-6.
CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC). This protein, being anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), is expressed ubiquitously on cells which are in contact with body fluids containing components. Recently, MAC formation has been reported to play an important role in pathogenesis of inflammatory diseases such as ischemia or autoimmune diseases. In this review, we describe the structure and biological activities of CD59, the pathogenic role of MAC formation, and discuss application of soluble molecules of CD59 for therapeutic use.
CD59在补体激活级联反应的最后一步发挥调节作用，抑制膜攻击复合物（MAC）的形成。这种蛋白质通过糖基磷脂酰肌醇（GPI）锚定在细胞膜上，在与含有补体成分的体液接触的细胞上普遍表达。最近，有报道称MAC的形成在缺血或自身免疫性疾病等炎症性疾病的发病机制中起重要作用。在这篇综述中，我们描述了CD59的结构和生物学活性、MAC形成的致病作用，并讨论了CD59可溶性分子在治疗中的应用。
