Antcliff R J, Trew D R
Department of Ophthalmology, Queen Mary's Hospital Sidcup, Sidcup, Kent, UK.
Eye (Lond). 1997;11 ( Pt 3):389-91. doi: 10.1038/eye.1997.82.
To determine whether the use of topical diclofenac sodium (diclofenac) pre-operatively improves the maintenance of per-operative mydriasis, in conjunction with irrigating solutions containing adrenaline.
Sixty-four consecutive patients undergoing phacoemulsification were randomised to receive either diclofenac or no diclofenac in conjunction with cyclopentolate 1% and phenylephrine 10% pre-operatively. They subsequently underwent routine phacoemulsification by one consultant surgeon. Irrigating solutions of balanced salt solution contained adrenaline 1:10(6). Pupil diameters were measured pre-sclerostomy, post-phacoemulsification, post-irrigation/aspiration and on day 1 post-operatively. These were then compared by Student's t-test.
The two groups were statistically similar in age and sex. The mean pre-sclerostomy pupillary diameters were 8.1 mm in both groups. The mean post-phacoemulsification diameters were 7.6 mm in those receiving diclofenac and 7.2 mm in those not (p = 0.03). The mean diameters after infusion/aspiration were 7.7 mm in those receiving diclofenac and 7.1 mm in those not (p = 0.008). The mean pupillary diameters on day 1 were 5.3 mm in those receiving diclofenac and 4.6 mm in those not (p = 0.003).
Diclofenac improves the maintenance of per-operative mydriasis, in the presence of irrigating solutions containing adrenaline.
确定术前使用双氯芬酸钠（双氯芬酸）与含肾上腺素的冲洗液联合使用是否能改善术中瞳孔散大的维持情况。
连续64例行超声乳化白内障吸除术的患者被随机分为两组，一组术前接受双氯芬酸，另一组不接受，两组均联合使用1%环喷托酯和10%去氧肾上腺素。随后由一位顾问外科医生为他们进行常规超声乳化白内障吸除术。平衡盐溶液冲洗液中含1:10(6)肾上腺素。在巩膜切口前、超声乳化白内障吸除术后、冲洗/抽吸后以及术后第1天测量瞳孔直径。然后通过学生t检验进行比较。
两组在年龄和性别上具有统计学相似性。两组巩膜切口前的平均瞳孔直径均为8.1mm。接受双氯芬酸的患者超声乳化白内障吸除术后的平均直径为7.6mm，未接受双氯芬酸的患者为7.2mm（p = 0.03）。接受双氯芬酸的患者输注/抽吸后的平均直径为7.7mm，未接受双氯芬酸的患者为7.1mm（p = 0.008）。接受双氯芬酸的患者术后第1天的平均瞳孔直径为5.3mm，未接受双氯芬酸的患者为4.6mm（p = 0.003）。
在存在含肾上腺素冲洗液的情况下，双氯芬酸可改善术中瞳孔散大的维持情况。
