Boyd M E, Garceau R
Am J Obstet Gynecol. 1976 Jul 1;125(5):581-5. doi: 10.1016/0002-9378(76)90776-6.
Prophylactic antibiotics were given postoperatively to a consecutive series of 74 patients who underwent vaginal hysterectomy. Antibiotics were administered in the immediate postoperative period. There was a highly significant decrease in febrile morbidity in the treated group compared to 190 control subjects having similar surgery but treated with antibiotics only on the appearance of fever and/or other signs of infection. There was a failure to relate the increased febrile morbidity in the control group to patient's age, menopausal state, type of catheterization, or to the type of operative procedure. The increased morbidity in the control group related only to the failure to use prophylactic antibiotics. The antibiotic-treated portion (58 per cent) of the control group had a longer period of hospitalization.
对连续74例行阴道子宫切除术的患者术后给予预防性抗生素。抗生素在术后即刻使用。与190例接受类似手术但仅在出现发热和/或其他感染迹象时才使用抗生素的对照组患者相比，治疗组的发热发病率显著降低。对照组发热发病率增加与患者年龄、绝经状态、导尿类型或手术方式无关。对照组发病率增加仅与未使用预防性抗生素有关。对照组中接受抗生素治疗的部分患者（58%）住院时间更长。
