Osborne N G, Wright R C, Dubay M
Am J Obstet Gynecol. 1979 Feb 15;133(4):374-8. doi: 10.1016/0002-9378(79)90054-1.
Laboratory results indicate that the endocervix may be a source of bacterial contamination when vaginal hysterectomy is performed. In a series of 160 consecutive vaginal hysterectomies in premenopausal women, hot conization of the cervix was performed prior to the scrub with an iodophore. No preoperative antibiotics were used in this series. The postoperative febrile morbidity rate was 4.3 per cent and the average stay was 4.5 days. These results are compared with those of three other groups: (1) patients who received a three-dose parenteral prophylactic antibiotic course with the first dose two hours prior to surgery had a febrile morbidity rate of 8.6 per cent. (2) In patients who had prophylactic antibiotics for five days with the first dose given intraoperatively, the febrile morbidity rate was 10.1 per cent. (3) The febrile morbidity rate in the group with no antibiotic prophylaxis or hot conization was 49.1 per cent. Laboratory and clinical data suggest that preoperative conization may be effective in the reduction of postoperative febrile morbidity.
实验室结果表明，在进行阴道子宫切除术时，子宫颈管内膜可能是细菌污染的来源。在一系列针对绝经前女性的160例连续阴道子宫切除术中，在使用碘伏擦洗前先进行了宫颈热锥切术。该系列研究中未使用术前抗生素。术后发热发病率为4.3%，平均住院时间为4.5天。这些结果与其他三组进行了比较：（1）在手术前两小时接受三剂肠胃外预防性抗生素疗程的患者，发热发病率为8.6%。（2）在术中给予第一剂并接受五天预防性抗生素治疗的患者中，发热发病率为10.1%。（3）未进行抗生素预防或热锥切术的组中，发热发病率为49.1%。实验室和临床数据表明，术前锥切术可能有效地降低术后发热发病率。
