Heaney L G, McCrea P, Buick B, MacMahon J
Department of Respiratory Medicine, Belfast City Hospital, Northern Ireland.
Occup Med (Lond). 1997 Sep;47(7):397-400. doi: 10.1093/occmed/47.7.397.
We describe a case of a 28 year old brewery worker who developed asthma whilst grinding malt. Lung function measurements demonstrated deterioration and improvement in lung function associated with work and absence from work. Inhalation challenge with ground malt from the brewery was positive but with ground malt from another source was negative suggesting a contaminant of the malt was responsible. Culture of the brewery malt showed heavy contamination with Aspergillus niger, but A. niger skin test was negative and aspergillus-specific IgG was not detected in the patients serum. Removal of the subject from the grinding room resulted in resolution of symptoms and normal lung function. We discuss the role of A. niger as an aetiological agent for occupational asthma with reference to the above case.
我们描述了一例28岁的啤酒厂工人，他在研磨麦芽时患上了哮喘。肺功能测量显示，肺功能随着工作和缺勤出现恶化和改善。用该啤酒厂研磨的麦芽进行吸入激发试验呈阳性，但用另一个来源研磨的麦芽进行试验呈阴性，这表明麦芽中的一种污染物是病因。对该啤酒厂的麦芽进行培养显示，被黑曲霉严重污染，但黑曲霉皮肤试验呈阴性，且在患者血清中未检测到曲霉特异性IgG。将该工人调离研磨室后，症状消失，肺功能恢复正常。我们参照上述病例讨论了黑曲霉作为职业性哮喘病原体的作用。
