Traber P G
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Am J Physiol. 1997 Nov;273(5):G979-81. doi: 10.1152/ajpgi.1997.273.5.G979.
Coordination of gene transcription is a critical regulatory step in orchestrating developmental, differentiation, and adaptation processes in the mammalian intestinal epithelium. An understanding of the regulatory network of nuclear proteins that direct transcriptional initiation of intestinal genes will provide insight into the mechanisms of normal development and differentiation as well as disease processes such as neoplasia.
基因转录的协调是哺乳动物肠道上皮细胞中调控发育、分化和适应过程的关键调控步骤。了解指导肠道基因转录起始的核蛋白调控网络，将有助于深入了解正常发育和分化的机制以及肿瘤形成等疾病过程。
