Traber P G
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):911-4. doi: 10.1098/rstb.1998.0255.
Coordination of gene transcription is a critical regulatory step in orchestrating developmental, differentiation and adaptation processes in the mammalian intestinal epithelium. Insight into these mechanisms has been gained by the study of transcriptional regulation of the sucrase-isomaltase gene. An understanding of the regulatory network of nuclear proteins that direct transcriptional initiation of intestinal genes such as sucrase-isomaltase will provide insight into the mechanisms of normal development and differentiation as well as disease processes such as neoplasia.
基因转录的协调是调控哺乳动物肠道上皮细胞发育、分化和适应过程的关键步骤。通过对蔗糖酶 - 异麦芽糖酶基因转录调控的研究，我们对这些机制有了更深入的了解。了解指导肠道基因（如蔗糖酶 - 异麦芽糖酶）转录起始的核蛋白调控网络，将有助于深入了解正常发育和分化的机制，以及肿瘤形成等疾病过程。
