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语义关系与阿尔茨海默病:功能知识方面的早期且不成比例的缺陷

Semantic relations and Alzheimer's disease: an early and disproportionate deficit in functional knowledge.

作者信息

Johnson M K, Hermann A M

机构信息

Department of Psychology, Princeton University, New Jersey 08544, USA.

出版信息

J Int Neuropsychol Soc. 1995 Nov;1(6):568-74. doi: 10.1017/s1355617700000709.

DOI:10.1017/s1355617700000709
PMID:9375244
Abstract

This experiment explored knowledge of four types of semantic relations (superordinate category, part, property, and function) in Alzheimer's disease (AD) subjects and age- and education-matched controls. Moderate AD subjects showed the greatest disruption on functional relations, intermediate disruption on part and property relations, and the least disruption on category relations; mild AD subjects showed a similar pattern but significant deficits only on functions. We suggest that the disproportionate deficit on functions reflects a greater cognitive complexity of functions than other semantic relations that renders them more vulnerable either to disrupted processing or to structural degradation of the network of associations among semantic concepts.

摘要

本实验探究了阿尔茨海默病(AD)患者以及年龄和教育程度匹配的对照组对四种语义关系(上位类别、部分、属性和功能)的认知情况。中度AD患者在功能关系上的破坏最为严重,在部分和属性关系上的破坏程度次之,在类别关系上的破坏程度最小;轻度AD患者表现出类似的模式,但仅在功能方面存在显著缺陷。我们认为,功能方面不成比例的缺陷反映出功能比其他语义关系具有更高的认知复杂性,这使得它们更容易受到加工过程中断或语义概念之间联想网络结构退化的影响。

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Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: patterns of functional MRI activation.
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