LeLorier J, Hedtke J L, Shideman F E
Am J Physiol. 1976 Jun;230(6):1545-9. doi: 10.1152/ajplegacy.1976.230.6.1545.
A decrease in the capacity of the sympathetic nervous system of hypertensive rats to take up norepinephrine (NE) has been previously described. In the present study, rats were made hypertensive by one of the following technics: "adrenal regeneration," figure-of-eight knot around one kidney, ingestion of a 10% NaCl solution. After 2 mo, the adrenal regeneration rats were hypertensive, and there was a significant decrease in the capacity of their hearts to take up NE as well as a significant increase in the inotropic response to the amine. Similar results were obtained with hearts and aortic strips of renal hypertensive rats, as well as of rats made hypertensive by drinking a 10% NaCl solution. In renal hypertensive rats, there was no appreciable difference in the time of appearance of hypertension, the decrease in NE uptake by the heart or aorta, or the increase of the inotropic response. Previous work showing a decrease of NE uptake in rats made hypertensive by administration of deoxycorticosterone has been confirmed utilizing three other models of the disease.
先前已有描述，高血压大鼠交感神经系统摄取去甲肾上腺素（NE）的能力下降。在本研究中，通过以下技术之一使大鼠患高血压：“肾上腺再生”、在一侧肾脏周围打8字形结、摄入10%的氯化钠溶液。2个月后，肾上腺再生大鼠出现高血压，其心脏摄取NE的能力显著下降，对该胺的变力反应也显著增加。肾性高血压大鼠以及因饮用10%氯化钠溶液而患高血压的大鼠的心脏和主动脉条也得到了类似结果。在肾性高血压大鼠中，高血压出现的时间、心脏或主动脉对NE摄取的减少以及变力反应的增加均无明显差异。利用该疾病的其他三种模型证实了先前的研究结果，即给予脱氧皮质酮使大鼠患高血压后NE摄取减少。
