Millen F J, Rainey M G, Hows J M, Burton P A, Irvine G H, Swirsky D
Southmead Hospital NHS Trust, Bristol.
Br J Haematol. 1997 Nov;99(2):410-4. doi: 10.1046/j.1365-2141.1997.3683184.x.
We report a case of oral squamous cell carcinoma (SCC) originating in the buccal mucosa of an 18-year-old female patient with chronic graft-versus-host disease (GVHD) 9 years after HLA-identical sibling bone marrow transplantation (BMT) for Fanconi anaemia (FA). The case highlights the problems of malignant change in FA and also the increased risk of second malignancy after BMT. The literature is reviewed with regard to previous cases and the possible aetiology of tumour formation. A high index of suspicion to any epithelial lesion in FA is appropriate so that early diagnosis may lead to improved prognosis.
我们报告了一例口腔鳞状细胞癌（SCC）病例，该病例发生在一名18岁女性患者的颊黏膜，该患者因范可尼贫血（FA）接受 HLA 全相合同胞骨髓移植（BMT）9年后出现慢性移植物抗宿主病（GVHD）。该病例突出了FA中发生恶性病变的问题以及BMT后发生第二原发性恶性肿瘤的风险增加。本文回顾了以往病例及肿瘤形成的可能病因相关文献。对FA中的任何上皮病变保持高度怀疑指数是恰当的，以便早期诊断可能改善预后。
