Tapanainen J S, Aittomäki K, Huhtaniemi I T
Ann Med. 1997 Aug;29(4):265-6. doi: 10.3109/07853899708999345.
Follicle-stimulating hormone (FSH) has been considered essential for normal ovarian follicular development and spermatogenesis. Although this concept remains valid, the recent reports of defects in genes encoding FSH and its receptor (FSHR) have altered the concepts, particularly with regard to the role of FSH in spermatogenesis. Complete FSH resistance caused by a mutation of the FSHR gene has demonstrated that normal FSH action is an absolute requirement for female fertility, but spermatogenesis and male fertility are possible without FSH action. Thus, while normal ovarian function is critically dependent on normal FSH action, male fertility is relatively independent of this hormone. The finding contradicts the potential of inhibition of FSH secretion or action as a means of male contraception.
促卵泡激素（FSH）一直被认为对正常的卵巢卵泡发育和精子发生至关重要。尽管这一概念仍然成立，但最近关于编码FSH及其受体（FSHR）的基因缺陷的报道改变了这些概念，特别是关于FSH在精子发生中的作用。由FSHR基因突变引起的完全FSH抵抗表明，正常的FSH作用是女性生育的绝对必要条件，但没有FSH作用时精子发生和男性生育也是可能的。因此，虽然正常的卵巢功能严重依赖于正常的FSH作用，但男性生育相对独立于这种激素。这一发现与抑制FSH分泌或作用作为男性避孕手段的可能性相矛盾。
