Ulloa-Aguirre Alfredo, Zariñán Teresa, Pasapera Ana Ma, Casas-González Patricia, Dias James A
Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Apartado Postal 99-065, Unidad Independencia, C.P. 10101 Mexico, D.F., Mexico.
Endocrine. 2007 Dec;32(3):251-63. doi: 10.1007/s12020-008-9041-6. Epub 2008 Feb 2.
Follicle-stimulating hormone (FSH) is a glycoprotein hormone produced by the anterior pituitary gland. This gonadotropin plays an essential role in reproduction. Its receptor (FSHR) belongs to the superfamily of G protein-coupled receptors (GPCR), specifically the family of rhodopsin-like receptors. Agonist binding to the FSHR triggers the rapid activation of multiple signaling cascades, mainly the cAMP-adenylyl cyclase-protein kinase A cascade, that impact diverse biological effects of FSH in the gonads. As in other G protein-coupled receptors, the several cytoplasmic domains of the FSHR are involved in signal transduction and termination of the FSH signal. Here we summarize some recent information on the signaling cascades activated by FSH as well as on the role of the intracytoplasmic domains of the FSHR in coupling to membrane and cytosolic proteins linked to key biological functions regulated by the FSH-FSHR system.
促卵泡生成素（FSH）是一种由腺垂体产生的糖蛋白激素。这种促性腺激素在生殖过程中起着至关重要的作用。其受体（FSHR）属于G蛋白偶联受体（GPCR）超家族，具体为视紫红质样受体家族。激动剂与FSHR结合会触发多个信号级联反应的快速激活，主要是cAMP-腺苷酸环化酶-蛋白激酶A级联反应，这些反应会影响FSH在性腺中的多种生物学效应。与其他G蛋白偶联受体一样，FSHR的几个胞质结构域参与FSH信号的转导和终止。在这里，我们总结了一些关于FSH激活的信号级联反应以及FSHR胞质结构域在与膜蛋白和胞质蛋白偶联中所起作用的最新信息，这些膜蛋白和胞质蛋白与FSH-FSHR系统调节的关键生物学功能相关。
