Menéndez Martínez M A, Pérez De Oteyza C, Muro García R, García Cortés A, Pastor Gómez J M
Unidad VIH, Hospital Militar Gómez Ulla, Universidad Complutense, Madrid.
An Med Interna. 1997 Aug;14(8):399-402.
To establish the difference between the evolutive clinical categories (CDC/93) of the HIV infection, on the basis of diverse laboratory parameters.
332 samples of blood, from 118 patients with HIV infection revised every three months from 1986, were studied. Determinations: haematologic, biochemical and immunologic study. Classification in each review by CDC/93 system. Statistical analysis (R-SIGMA) comparing by ANOVA and NEWMANN-KEULS the averages of the laboratory variables in the clinics categories ("A", "B" and "C").
There are very significant laboratory differences (p < 0.01) between the asymptomatic patients ("A") and the AIDS cases ("C"), with important decrease of hemoglobin, platelets, leukocytes, albumin, CD4+ and CD8+ T cells in the "C" category. On the contrary there is a marked increase of erythrocyte sedimentation, triglycerides, immunoglobulin A and beta 2-microglobulin in those patients with AIDS.
AIDS patients present very significant differences in ten laboratory parameters, compared to the asymptomatic HIV infected patients. The follow up of these parameters may have prognostic value of AIDS evolution and be useful for the therapeutic decision making.
基于多种实验室参数，确定HIV感染的演变临床类别（CDC/93）之间的差异。
研究了1986年起每三个月复查一次的118例HIV感染患者的332份血样。检测项目：血液学、生物化学和免疫学研究。每次复查时按照CDC/93系统进行分类。采用方差分析和纽曼-丘尔斯检验（R-SIGMA）对临床类别（“A”、“B”和“C”）中实验室变量的平均值进行统计学分析。
无症状患者（“A”）与艾滋病患者（“C”）之间存在非常显著的实验室差异（p < 0.01），“C”类患者的血红蛋白、血小板、白细胞、白蛋白、CD4 +和CD8 + T细胞显著减少。相反，艾滋病患者的红细胞沉降率、甘油三酯、免疫球蛋白A和β2-微球蛋白显著升高。
与无症状HIV感染患者相比，艾滋病患者在十个实验室参数上存在非常显著的差异。对这些参数的随访可能对艾滋病的演变具有预后价值，并有助于治疗决策。
