Han S M
Department of Pharmaceutical Technologies (UP9200), Smithkline Beecham Pharmaceuticals, Collegeville, PA 19426, USA.
Biomed Chromatogr. 1997 Sep-Oct;11(5):259-71. doi: 10.1002/(SICI)1099-0801(199709)11:5<259::AID-BMC701>3.0.CO;2-U.
Due to their identical chemical and physical properties, the separation of enantiomers has been considered one of the most difficult challenges in chemistry from both an analytical or a preparative viewpoint. With the development and commercialization of many new or improved chiral stationary phases and chiral additives, interest in enantiomeric separation by HPLC has grown tremendously in the last two decades. Cyclodextrins and modified cyclodextrins are widely used chiral selectors. They are used as either the chiral stationary phases, as chiral mobile phase additives, or as chiral counter-ions. This review describes the historical development of derivatized and underivatized cyclodextrins in HPLC and their various applications.
由于对映体具有相同的化学和物理性质，从分析或制备的角度来看，对映体的分离一直被认为是化学领域最具挑战性的难题之一。随着许多新型或改进的手性固定相和手性添加剂的开发与商业化，在过去二十年中，高效液相色谱法（HPLC）对映体分离的研究兴趣急剧增长。环糊精及其改性产物是广泛使用的手性选择剂。它们既可以用作手性固定相，也可以用作手性流动相添加剂，或者用作手性抗衡离子。本文综述了衍生化和未衍生化环糊精在高效液相色谱中的历史发展及其各种应用。
