Bressolle F, Audran M, Pham T N, Vallon J J
Laboratoire de Pharmacocinetique, Faculté de Pharmacie, Université de Montpellier I, France.
J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):303-36. doi: 10.1016/s0378-4347(96)00263-0.
Investigation of individual drug enantiomers is required in pharmacokinetic and pharmacodynamic studies of drugs with a chiral centre. Cyclodextrins (CDs) are extensively used in high-performance liquid chromatography as stationary phases bonded to a solid support or as mobile phase additives in HPLC and capillary electrophoresis (CE) for the separation of chiral compounds. We describe here the basis for the liquid chromatographic and capillary electrophoretic resolution of drug enantiomers and the factors affecting their enantiomeric separation. This review covers the use of CDs and some of their derivatives in studies of compounds of pharmacological interest.
对于具有手性中心的药物进行药代动力学和药效学研究时，需要对单个药物对映体进行研究。环糊精（CDs）在高效液相色谱中被广泛用作键合到固体载体上的固定相，或用作高效液相色谱和毛细管电泳（CE）中的流动相添加剂，用于分离手性化合物。我们在此描述药物对映体的液相色谱和毛细管电泳拆分的基础以及影响其对映体分离的因素。本综述涵盖了环糊精及其一些衍生物在药理学相关化合物研究中的应用。
