Pogorelyĭ V E, Arl't A V, Gaevyĭ M D, Smirnov L D, Gatsura V V
Eksp Klin Farmakol. 1997 Jul-Aug;60(4):22-4.
Acute experiments on nembutal anesthetized rats showed improvement of cerebral blood flow autoregulation in the postischemic period under the effect of mexidol and the new 3-hydroxypyridine (3-HOP) derivatives LBK-10 and LBK-38 administered for prophylactic and therapeutic, purposes. The role of dopaminergic activity, solubility in lipids, and other factors in the mechanism of the activity of 3-HOP derivatives is analysed.
对戊巴比妥麻醉大鼠进行的急性实验表明，在预防性和治疗性使用美西多宁以及新型3-羟基吡啶（3-HOP）衍生物LBK-10和LBK-38的情况下，缺血后时期脑血流自动调节功能得到改善。分析了多巴胺能活性、脂溶性及其他因素在3-HOP衍生物活性机制中的作用。
