[尼司特罗醇心血管活性的实验研究]
[An experimental study of the cardiovascular activity of nistranol].
作者信息
Sergeev P V, Karachentsev A N, Isaeva S A, Mambetova A Zh
出版信息
Eksp Klin Farmakol. 1997 Jul-Aug;60(4):25-8.
In concentrations of > or = 10(-5) mol/liter nistranol (11 beta-nitroxy-9 alpha-hydroxy-ethynylestradiol-diacetate) demonstrated cardiac and vascular activity in vitro. It caused concentration-dependent and reversible increase of the contractile parameters of an isolated atrial appendage of rats. A three-phase effect of nistranol on a isolated rat thoracic aorta was encountered: vasodilatation-vasoconstriction-vasodilatation. Anti-ischemic and antinecrotic effects of nistranol were noted in experimental myocardial infarction.
当浓度≥10⁻⁵摩尔/升时，尼司特罗醇（11β-硝基氧基-9α-羟基-乙炔雌二醇二乙酸酯）在体外表现出心脏和血管活性。它使大鼠离体心耳的收缩参数呈浓度依赖性且可逆性增加。观察到尼司特罗醇对离体大鼠胸主动脉有三相作用：血管舒张-血管收缩-血管舒张。在实验性心肌梗死中发现了尼司特罗醇的抗缺血和抗坏死作用。
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