Obuchowicz A, Obuchowicz E
III Department of Pediatrics, Silesian Academy of Medicine, Batorego, Poland.
Int J Obes Relat Metab Disord. 1997 Sep;21(9):783-8. doi: 10.1038/sj.ijo.0800474.
To investigate the relationship between plasma beta-endorphin (beta-end) and insulin concentrations and 1) body fat, and 2) nutritional parameters in overweight or obese prepubertal children.
Cross-sectional study on plasma beta-end and insulin concentrations, body fat, indirect parameters of appetite namely daily energy and macronutrient intake.
143 (67 boys and 76 girls) overweight or obese children (group I) and 48 (27 boys and 21 girls) healthy children with normal parameters of somatic development (group II). Age: 5.8-9.6 y.
Weight, height and subcutaneous skinfold thicknesses, plasma beta-end and insulin concentrations, diet history for energy and macronutrient intake.
Group I was characterised by significantly higher average concentrations of beta-end and insulin in comparison to the control group. The analysis of these concentrations in the subgroups in relation to the percentage of body fat indicates that beta-end concentrations increased more than insulin concentrations with increasing fatness. A significantly positive correlation between beta-end and insulin levels was only noted in group I. Also, only in this group was there a significant positive correlation between beta-end levels and energy and macronutrient intake. In both groups the percentage of energy intake which was fat, correlated positively with beta-end concentrations. Furthermore energy and fat intakes showed a significant positive correlation with insulin levels in both groups.
beta-endorphin and insulin concentrations in overweight and obese prepubertal children are not only higher than in non-obese children but also are positively correlated with each other and with the percentage of body fat. The relationship between plasma beta-end levels and food intake shows that the beta-end level may be able to be used as an indicator of appetite in overweight and obese prepubertal children whose food intake is not restricted.
探讨血浆β-内啡肽（β-end）与胰岛素浓度之间的关系，以及1）体脂，和2）超重或肥胖青春期前儿童的营养参数。
关于血浆β-end和胰岛素浓度、体脂、食欲间接参数（即每日能量和常量营养素摄入量）的横断面研究。
143名（67名男孩和76名女孩）超重或肥胖儿童（I组）和48名（27名男孩和21名女孩）身体发育参数正常的健康儿童（II组）。年龄：5.8 - 9.6岁。
体重、身高和皮下皮褶厚度、血浆β-end和胰岛素浓度、能量和常量营养素摄入量的饮食史。
与对照组相比，I组的β-end和胰岛素平均浓度显著更高。根据体脂百分比对亚组中这些浓度进行分析表明，随着肥胖程度增加，β-end浓度的升高幅度大于胰岛素浓度。仅在I组中发现β-end与胰岛素水平之间存在显著正相关。同样，也仅在该组中，β-end水平与能量和常量营养素摄入量之间存在显著正相关。在两组中，脂肪能量摄入量百分比均与β-end浓度呈正相关。此外，两组中的能量和脂肪摄入量均与胰岛素水平呈显著正相关。
超重和肥胖青春期前儿童的β-内啡肽和胰岛素浓度不仅高于非肥胖儿童，而且彼此之间以及与体脂百分比均呈正相关。血浆β-end水平与食物摄入量之间的关系表明，β-end水平可能能够用作食物摄入量不受限制的超重和肥胖青春期前儿童食欲的指标。
