Tebib J G, Reynaud C, Cedoz J P, Letroublon M C, Niveleau A
CHLS, Pierre Bénite, France.
Br J Rheumatol. 1997 Sep;36(9):990-5. doi: 10.1093/rheumatology/36.9.990.
The levels of the five methylated nucleosides pseudouridine (psi-Urd), 1-methyladenosine (1-MeAdo), 4 acetylcytidine (4-AcCyd), 1 methylinosine (1-Melno) and 7 methylguanosine (7-MeGuo) resulting from RNA degradation were examined in the urine of rheumatoid arthritis (RA) patients. Of these five, 1-MeAdo and psi-Urd were correlated with the active phase of the disease, while two others (4-AcCyd and 1-Melno), which require further evaluation, appeared to be linked to the prognosis of the disease. As RNA turnover is closely associated with cell proliferation, including that of lymphocytes in RA, there may be a hitherto unsuspected benefit in measuring 1-MeAdo and psi-Urd as biochemical markers of RA disease activity.
在类风湿性关节炎（RA）患者的尿液中检测了由RNA降解产生的五种甲基化核苷——假尿苷（ψ-Urd）、1-甲基腺苷（1-MeAdo）、4-乙酰胞苷（4-AcCyd）、1-甲基肌苷（1-Melno）和7-甲基鸟苷（7-MeGuo）的水平。在这五种核苷中，1-MeAdo和ψ-Urd与疾病的活动期相关，而另外两种（4-AcCyd和1-Melno）需要进一步评估，似乎与疾病的预后有关。由于RNA周转与细胞增殖密切相关，包括类风湿性关节炎中淋巴细胞的增殖，因此将1-MeAdo和ψ-Urd作为类风湿性关节炎疾病活动的生化标志物进行检测，可能会有迄今未被察觉的益处。
