Barreca T, Franceschini R, Cataldi A, Garibaldi A, Cianciosi P, Rolandi E
Department of Internal Medicine, University of Genoa, Italy.
Clin Neuropharmacol. 1993 Dec;16(6):555-8.
The aim of the study was to investigate the effects of a new serotoninergic drug, sumatriptan, on arginine vasopressin secretion in humans. Plasma vasopressin concentrations were determined in eight healthy volunteers, before and after administration of 6 mg of sumatriptan, or placebo. No changes in hormone levels were found after sumatriptan or placebo administration. The results suggest that in humans serotoninergic mechanisms, which modulate vasopressin secretion, do not involve the serotonin receptor activated by sumatriptan.
该研究的目的是调查一种新型血清素能药物舒马曲坦对人体精氨酸加压素分泌的影响。在8名健康志愿者中，分别于给予6毫克舒马曲坦或安慰剂之前及之后，测定血浆加压素浓度。给予舒马曲坦或安慰剂后，未发现激素水平有变化。结果表明，在人体中，调节加压素分泌的血清素能机制并不涉及由舒马曲坦激活的血清素受体。
