Rifkin R, Reed B, Hetzel F, Chen K
Rocky Mountain Cancer Center, University of Colorado, Health Sciences Center, Denver, USA.
Clin Ther. 1997 Jul-Aug;19(4):639-41. doi: 10.1016/s0149-2918(97)80089-6.
A 26-year-old man with basal cell nevus syndrome presented to the Rocky Mountain Cancer Center (Denver, Colorado) for treatment of several basal cell carcinomas with photodynamic therapy using tin ethyl etiopurpurin (SnET2). The patient was of northern European descent, had type I skin (always burns, never tans), and had a 10-year history of multifocal basal cell carcinomas. The patient had a family history of Gorlin's syndrome (basal cell nevus syndrome); the syndrome had been diagnosed in this patient in 1985. The patient was enrolled in a Phase I/II clinical trial. He was given 1.2 mg/kg (94 mg total) of SnET2 via intravenous infusion; he returned to the clinic the following day for red light application. Thirteen lesions, in 12 treatment fields, were illuminated with light totaling 200 J/cm2 at a fluence of 150 mW/cm2. At the 3-month follow-up examination, all tumors were graded as having a complete response by modified AIDS Clinical Trial Guidelines oncologic standards. No evidence of recurrence has been noted during the 6-month follow-up period.
一名患有基底细胞痣综合征的26岁男性前往落基山癌症中心（科罗拉多州丹佛市），接受使用乙磺基四羟基卟啉锡（SnET2）的光动力疗法治疗多处基底细胞癌。该患者为北欧血统，具有I型皮肤（总是晒伤，从不晒黑），并有10年多灶性基底细胞癌病史。患者有戈林综合征（基底细胞痣综合征）家族史；该综合征于1985年在该患者中被诊断出来。该患者参加了一项I/II期临床试验。通过静脉输注给予他1.2 mg/kg（总计94 mg）的SnET2；他第二天返回诊所接受红光照射。在12个治疗区域的13个病变部位，以150 mW/cm2的能量密度照射总能量为200 J/cm2的光。在3个月的随访检查中，根据修改后的艾滋病临床试验指南肿瘤学标准，所有肿瘤均被评为完全缓解。在6个月的随访期内未发现复发迹象。
