Santoro O, Bandieramonte G, Melloni E, Marchesini R, Zunino F, Lepera P, De Palo G
Department of Diagnostic Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Cancer Res. 1990 Aug 1;50(15):4501-3.
The efficacy of an originally developed photodynamic approach, using topical administration of tetraphenylporphinesulfonate as the photosensitizer, was evaluated in a series of 292 basal cell carcinoma lesions (less than 2-mm thick) in 50 treated patients. The lack of indication for conventional therapies was the main selection criterion. The photosensitizing agent (2% solution) was topically applied at 0.1 ml/cm2, followed by light irradiation with a dye laser emitting at 645 nm (120 or 150 J/cm2). After initial treatment, all lesions responded, with 273 (93.5%) complete responses. Recurrences were observed in 29 (10.6%). A second application of photoradiation was performed in 15 persistent lesions and 11 relapsed lesions, producing 19/26 complete responses. Our results suggest that this technique can be considered a promising alternative treatment modality in selected cases of superficial basal cell carcinomas.
使用四苯基卟啉磺酸盐作为光敏剂进行局部给药，对最初开发的光动力疗法的疗效进行了评估，该研究纳入了50例接受治疗患者的292个基底细胞癌病灶（厚度小于2毫米）。主要选择标准是缺乏传统治疗的指征。将光敏剂（2%溶液）以0.1 ml/cm² 的剂量局部应用，随后用发射波长为645 nm的染料激光进行光照射（120或150 J/cm²）。初始治疗后，所有病灶均有反应，273个（93.5%）完全缓解。观察到29个（10.6%）复发。对15个持续性病灶和11个复发病灶进行了第二次光辐射治疗，产生了19/26个完全缓解。我们的结果表明，在选定的浅表基底细胞癌病例中，该技术可被视为一种有前景的替代治疗方式。
