Zajkowska J M, Pancewicz S A, Kucharewicz B, Hermanowska-Szpakowicz T, Szmitkowski M, Krupa W
Kliniki Chorób Pasozytniczych i Neuroinfekcji, Białymstoku.
Pol Merkur Lekarski. 1997 Apr;2(10):250-3.
The levels of albumin and immunoglobulins G, A, M were determined by using nephelometry technique in the cerebrospinal fluid and serum in 14 adults with tick borne meningoencephalitis at the beginning and after four weeks of disease. Intra blood-brain synthesis of IgG, IgA, IgM was evaluated by indexes of synthesis (Tibbling formula). The blood-brain integrity was estimated by CSF/serum albumin ratio. Increased albumin and immunoglobulins G, A, M levels were demonstrated in first examination and only elevated levels of albumin and immunoglobulin M lasted after four weeks. Albumin level in cerebrospinal fluid and albumin ratio were elevated in both examinations. The serum levels of albumin and immunoglobulins were similar in first and second examination. On the basis these results we conclude that in tested patients blood-brain integrity was disturbed still after four weeks of disease.
采用散射比浊法测定了14例蜱传脑膜脑炎成年患者疾病初期及发病四周后的脑脊液和血清中白蛋白、免疫球蛋白G、A、M的水平。通过合成指数（蒂布林公式）评估IgG、IgA、IgM的血脑内合成情况。通过脑脊液/血清白蛋白比值评估血脑屏障的完整性。首次检查时白蛋白、免疫球蛋白G、A、M水平升高，四周后仅白蛋白和免疫球蛋白M水平持续升高。两次检查中脑脊液白蛋白水平及白蛋白比值均升高。首次和第二次检查时血清白蛋白和免疫球蛋白水平相似。基于这些结果，我们得出结论，在受试患者中，疾病四周后血脑屏障完整性仍受到破坏。
