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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tuovinen K, Kaliste-Korhonen E, Hänninen O

Department of Physiology, University of Kuopio, Finland.

Gen Pharmacol. 1997 Sep;29(3):333-5. doi: 10.1016/s0306-3623(96)00485-5.

Gender differences in the toxicity of diisopropylfluorophosphate (DFP; 4.0 mg/kg) and isopropyl methylphosphonofluoridate (sarin; 0.3 mg/kg) were studied in mice. 2. The animals were killed 3 hr after intraperitoneal (IP) injection of the organophosphates (OPs). 3. Although the activity of plasma butyrylcholinesterase (BChE) was two-fold higher and carboxylesterase (CaE) 1.3-fold higher in females than in males, the elevated BChE and CaE activities did not prevent inhibition of the enzyme by OPs in brain. 4. The differences in plasma BChE and CaE activities do not seem to be critical for the detoxification of OPs used in this study.

研究了二异丙基氟磷酸酯（DFP；4.0毫克/千克）和甲基异丙基膦酰氟（沙林；0.3毫克/千克）对小鼠毒性的性别差异。2. 在腹腔注射有机磷酸酯（OPs）3小时后处死动物。3. 尽管雌性小鼠血浆丁酰胆碱酯酶（BChE）活性比雄性高两倍，羧酸酯酶（CaE）活性比雄性高1.3倍，但BChE和CaE活性升高并不能阻止OPs对脑内酶的抑制作用。4. 血浆BChE和CaE活性的差异似乎对本研究中使用的OPs解毒并不关键。

Tuovinen K, Kaliste-Korhonen E, Hänninen O

Department of Physiology, University of Kuopio, Finland.

Gen Pharmacol. 1997 Sep;29(3):333-5. doi: 10.1016/s0306-3623(96)00485-5.

Gender differences in the toxicity of diisopropylfluorophosphate (DFP; 4.0 mg/kg) and isopropyl methylphosphonofluoridate (sarin; 0.3 mg/kg) were studied in mice. 2. The animals were killed 3 hr after intraperitoneal (IP) injection of the organophosphates (OPs). 3. Although the activity of plasma butyrylcholinesterase (BChE) was two-fold higher and carboxylesterase (CaE) 1.3-fold higher in females than in males, the elevated BChE and CaE activities did not prevent inhibition of the enzyme by OPs in brain. 4. The differences in plasma BChE and CaE activities do not seem to be critical for the detoxification of OPs used in this study.

研究了二异丙基氟磷酸酯（DFP；4.0毫克/千克）和甲基异丙基膦酰氟（沙林；0.3毫克/千克）对小鼠毒性的性别差异。2. 在腹腔注射有机磷酸酯（OPs）3小时后处死动物。3. 尽管雌性小鼠血浆丁酰胆碱酯酶（BChE）活性比雄性高两倍，羧酸酯酶（CaE）活性比雄性高1.3倍，但BChE和CaE活性升高并不能阻止OPs对脑内酶的抑制作用。4. 血浆BChE和CaE活性的差异似乎对本研究中使用的OPs解毒并不关键。