Pump K K
Am Rev Respir Dis. 1976 Jul;114(1):5-13. doi: 10.1164/arrd.1976.114.1.5.
To establish whether a correlation existed between emphysema and age, 24 lungs were used to measure the alveolar membrane fenestrations; the average area of 100 fenestrae was then plotted against age. Eighteen of these lungs were from patients 17 to 86 years of age with no history of respiratory ailments, whereas 6 lungs were from patients in whom an antemortem diagnosis of emphysema had been made. A significant, positive correlation between age and the area of fenestrae (t=2.4;p greater than 0.05) was found in the group of 18 lungs from patients with no respiratory ailements. The same could not be said categorically about the lungs from the emphysematous group, because the number of lungs examined was too small. We postulate that the pores of Kohn are part of the degenerating emphysematous process and are the first stage in the formation of fenestrae. A possible mechanism for the formation of fenestrae and their classification into 4 grades is presented.
为确定肺气肿与年龄之间是否存在相关性，使用24个肺来测量肺泡膜窗孔；然后将100个窗孔的平均面积与年龄作图。其中18个肺来自17至86岁无呼吸系统疾病史的患者，而6个肺来自生前已确诊为肺气肿的患者。在18个无呼吸系统疾病患者的肺组中，发现年龄与窗孔面积之间存在显著的正相关（t = 2.4；p大于0.05）。对于肺气肿组的肺，不能如此明确地说，因为检查的肺数量太少。我们推测，科恩孔是肺气肿退变过程的一部分，是窗孔形成的第一阶段。本文提出了窗孔形成的一种可能机制及其分为4级的分类方法。
