D'Errico A, Scarani P, Colosimo E, Spina M, Grigioni W F, Mancini A M
Department of Pathology, Bologna University, Italy.
Virchows Arch A Pathol Anat Histopathol. 1989;415(2):137-44. doi: 10.1007/BF00784351.
The modifications of the extracellular matrix (ExM) components in the alveolar parenchyma of elderly subjects were investigated using a panel of polyclonal antibodies. The elastic fibers showed a notable decrease along the alveolar walls while type III collagen increased when compared with that of non-elderly controls. No variations of these components were detectable in the alveolar ducts or in the respiratory bronchioli. An increase in the thickness of the alveolar basement membranes was detected in some of the subjects when antibodies against type IV collagen and laminin were used, while antibodies to fibronectin and type V collagen did not reveal any modifications compared with the controls. The modifications revealed in the lungs of the elderly can be related to the alterations of the elastic recoil and pulmonary compliance observed in these subjects.
使用一组多克隆抗体研究了老年受试者肺泡实质中细胞外基质（ExM）成分的变化。与非老年对照组相比，弹性纤维沿肺泡壁显著减少，而III型胶原蛋白增加。在肺泡管或呼吸细支气管中未检测到这些成分的变化。当使用抗IV型胶原蛋白和层粘连蛋白的抗体时，在一些受试者中检测到肺泡基底膜厚度增加，而与对照组相比，抗纤连蛋白和V型胶原蛋白的抗体未显示任何变化。在老年人肺部发现的这些变化可能与这些受试者中观察到的弹性回缩和肺顺应性改变有关。
