Christensen S T, Leick V, Rasmussen L, Wheatley D N
Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark.
Int Rev Cytol. 1998;177:181-253. doi: 10.1016/s0074-7696(08)62233-0.
Aspects of intercellular and intracellular signaling systems in cell survival, proliferation, differentiation, chemosensory behavior, and programmed cell death in free-living unicellular eukaryotes have been reviewed. Comparisons have been made with both bacteria and metazoa. The central organisms were flagellates (Trypanosoma, Leishmania, and Crithidia), slime molds (Dictyostelium), yeast cells (Saccharomyces cerevisiae), and ciliates (Paramecium, Euplotes, and Tetrahymena). There are two novel aspects in this review. First, cellular responses are viewed in an evolutionary perspective, rather than from the more prevailing one, in which the unicellular eukaryotes are seen by the mammalian organisms. Second, results obtained with cell cultures in minimal, chemically defined nutrient media at low cell densities where intercellular signaling is strongly reduced are discussed. These results shed light on control mechanisms and their cooperation inside the living cell. Intracellular systems have many common features in unicellular and multicellular organisms.
关于自由生活的单细胞真核生物中细胞存活、增殖、分化、化学感应行为和程序性细胞死亡过程中的细胞间和细胞内信号系统的各个方面已进行了综述。已将其与细菌和后生动物进行了比较。核心生物包括鞭毛虫（锥虫、利什曼原虫和短膜虫）、黏菌（盘基网柄菌）、酵母细胞（酿酒酵母）和纤毛虫（草履虫、真核浮游生物和四膜虫）。本综述有两个新颖之处。首先，细胞反应是从进化的角度来看待的，而不是从更普遍的角度，即哺乳动物看待单细胞真核生物的角度。其次，讨论了在最低限度的、化学成分明确的营养培养基中以低细胞密度进行细胞培养时获得的结果，此时细胞间信号传导大大减少。这些结果揭示了活细胞内的控制机制及其协作。单细胞和多细胞生物中的细胞内系统有许多共同特征。
