Bhat J G, Gluck M C, Lowenstein J, Baldwin D S
Ann Intern Med. 1976 Jun;84(6):677-82. doi: 10.7326/0003-4819-84-6-677.
One hundred fifty of 490 patients undergoing open heart surgery had renal failure attributable to cardiopulmonary bypass. In 69, serum creatinine concentrations did not exceed 2 mg/dl and returned to normal by the fourth postoperative day. In 60 patients, serum creatinine attained levels between 2 and 5 mg/dl, oliguria did not develop, and recovery of renal function occurred within 4 to 37 days. Serum creatinine increased to levels exceeding 5 mg/dl in 21 patients, 11 of whom were oliguric. Despite dialysis, 14 of these patients died from cardiac causes or sepsis. Prolonged cardiopulmonary bypass time, hypotension, oliguria, low output syndrome, and hemoglobinemia during open heart surgery correlated with the development of renal failure postoperatively. Although severe renal failure was an uncommon complication after open heart surgery, its occurrence carried a grave prognosis.
490例接受心脏直视手术的患者中，有150例出现了归因于体外循环的肾衰竭。其中69例患者血清肌酐浓度未超过2mg/dl，术后第4天恢复正常。60例患者血清肌酐水平达到2至5mg/dl，未出现少尿，肾功能在4至37天内恢复。21例患者血清肌酐升至超过5mg/dl，其中11例少尿。尽管进行了透析，这些患者中有14例死于心脏原因或败血症。心脏直视手术期间体外循环时间延长、低血压、少尿、低心排综合征和血红蛋白血症与术后肾衰竭的发生相关。虽然严重肾衰竭是心脏直视手术后不常见的并发症，但其发生预后严重。
