Sobel J D
Department of Internal Medicine, Wayne State University School of Medicine, Detroit Medical Center, Michigan, USA.
Infect Dis Clin North Am. 1997 Sep;11(3):531-49. doi: 10.1016/s0891-5520(05)70372-x.
In the last decade, there have been modest strides made in our understanding of the pathogenesis of urinary tract infections (UTIs). Matching the advances achieved in unraveling the complexities of bacterial virulence factors using molecular-genetic techniques has been a parallel increase in knowledge of host defense mechanisms. Host susceptibility to UTI in the past has been predominantly studied in patients with structural (obstruction) or functional abnormalities (diabetes mellitus); however, most patients with UTIs have no such demonstrable abnormalities, hence attention has now focused on host behavioral factors in addition to genetically determined cellular mechanisms that predispose to sporadic and recurrent UTI.
在过去十年中，我们对尿路感染（UTIs）发病机制的理解取得了一定进展。与利用分子遗传学技术在揭示细菌毒力因子复杂性方面取得的进展相匹配的是，我们对宿主防御机制的认识也在同步增加。过去，主要是在患有结构异常（梗阻）或功能异常（糖尿病）的患者中研究宿主对UTI的易感性；然而，大多数UTI患者并没有此类明显异常，因此现在除了易引发散发性和复发性UTI的基因决定的细胞机制外，注意力还集中在宿主行为因素上。
