尿路感染和肾盂肾炎期间的固有免疫反应。
The innate immune response during urinary tract infection and pyelonephritis.
作者信息
Spencer John David, Schwaderer Andrew L, Becknell Brian, Watson Joshua, Hains David S
机构信息
Department of Pediatrics, Division of Nephrology, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA,
出版信息
Pediatr Nephrol. 2014 Jul;29(7):1139-49. doi: 10.1007/s00467-013-2513-9. Epub 2013 Jun 5.
Abstract
Despite its proximity to the fecal flora, the urinary tract is considered sterile. The precise mechanisms by which the urinary tract maintains sterility are not well understood. Host immune responses are critically important in the antimicrobial defense of the urinary tract. During recent years, considerable advances have been made in our understanding of the mechanisms underlying immune homeostasis of the kidney and urinary tract. Dysfunctions in these immune mechanisms may result in acute disease, tissue destruction and overwhelming infection. The objective of this review is to provide an overview of the innate immune response in the urinary tract in response to microbial assault. In doing so, we focus on the role of antimicrobial peptides-a ubiquitous component of the innate immune response.
摘要
尽管尿路紧邻粪便菌群，但仍被认为是无菌的。尿路维持无菌状态的确切机制尚不清楚。宿主免疫反应在尿路的抗菌防御中至关重要。近年来，我们对肾脏和尿路免疫稳态的潜在机制的理解取得了相当大的进展。这些免疫机制的功能障碍可能导致急性疾病、组织破坏和严重感染。本综述的目的是概述尿路针对微生物攻击的固有免疫反应。在此过程中，我们重点关注抗菌肽——固有免疫反应中普遍存在的一个组成部分的作用。
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