Lee S H, Park S K, Seo M, Guk S M, Choi M H, Chai J Y
Department of Parasitology, Seoul National University College of Medicine, Korea.
J Parasitol. 1997 Oct;83(5):883-6.
Susceptibility to Gymnophalloides seoi infection was studied in 8 species of animals, including 7 strains of mice; the effects of immunosuppression on susceptibility were examined in C3H/HeN mice. One hundred metacercariae of G. seoi isolated from naturally infected oysters were orally administered to each animal. Worm recovery rate (WRR), worm dimensions, and the number of uterine eggs were obtained at day 3 and day 7 postinfection (PI). Average WRR from gerbils, hamsters, and cats at day 7 PI was 28.0%, 14.2%, and 10.9%, respectively, the former 2 figures of which were significantly higher than the rate of 0.0-4.0% from Sprague-Dawley rats, dogs, ducks, guinea pigs, and chicks. In the case of mice, average WRR at day 7 PI was 12.4% (KK strain), 11.8% (C3H/HeN), 9.6% (ICR), 6.4% (BALB/c), and 6.3% (ddY), respectively; the first 3 figures were significantly higher than the rates from other strains, which were 1.8% (A) and 0% (C57BL/6). At day 3 PI, WRR was much higher in all strains except C57BL/6. Worm maturation was the highest in C3H/HeN mice. Immunosuppression of C3H/HeN mice by injecting prednisolone for 7, 14, or 21 days prior to infection increased WRR at day 7 PI to 27.8%, 33.8%, or 67.5%, respectively. The results show that gerbils, hamsters, cats, and KK, C3H/HeN, ICR. BALB/c, and ddY mice are laboratory hosts that are fairly susceptible to G. seoi infection. In C3H/HeN mice, susceptibility was markedly enhanced by immunosuppression.
研究了包括7个品系小鼠在内的8种动物对西氏裸茎吸虫感染的易感性；在C3H/HeN小鼠中检测了免疫抑制对易感性的影响。将从自然感染牡蛎中分离出的100个西氏裸茎吸虫囊蚴经口给予每只动物。在感染后第3天和第7天获得虫体回收率（WRR）、虫体尺寸和子宫内虫卵数量。感染后第7天，沙鼠、仓鼠和猫的平均WRR分别为28.0%、14.2%和10.9%，前两个数值显著高于斯普拉格-道利大鼠、狗、鸭、豚鼠和鸡的0.0 - 4.0%的回收率。就小鼠而言，感染后第7天的平均WRR分别为12.4%（KK品系）、11.8%（C3H/HeN）、9.6%（ICR）、6.4%（BALB/c）和6.3%（ddY）；前三个数值显著高于其他品系的回收率，其他品系为1.8%（A）和0%（C57BL/6）。在感染后第3天，除C57BL/6外的所有品系WRR都高得多。C3H/HeN小鼠的虫体成熟度最高。在感染前7天、14天或21天注射泼尼松龙对C3H/HeN小鼠进行免疫抑制，感染后第7天的WRR分别增加到27.8%、33.8%或67.5%。结果表明，沙鼠、仓鼠、猫以及KK、C3H/HeN、ICR、BALB/c和ddY小鼠是对西氏裸茎吸虫感染相当易感的实验宿主。在C3H/HeN小鼠中，免疫抑制显著增强了易感性。
