Yamazaki T, Nakajima Y, Niho Y, Hosono T, Kurashige T, Kinjo J, Nohara T
Tsukuba Research Institute, Ohta's Isan Co. Ltd., Ibaraki, Japan.
J Pharm Pharmacol. 1997 Aug;49(8):831-3. doi: 10.1111/j.2042-7158.1997.tb06122.x.
Kakkalide, one of the major isoflavonoid components of Puerariae flos, has been investigated for its effect on ethanol-induced intoxication and on hepatic injury, including hyperglycaemia, in mice. Kakkalide reduced mortality associated with administration of ethanol. At doses of 100 and 200 mg kg-1 the effect of kakkalide was significant. The same dose of kakkalide prevented increased serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activity. At a dose of 200 mg kg-1 it also counteracted ethanol-induced elevation of glucose levels. These results suggest that kakkalide might be useful for counteracting the effects of alcohol and might be effective for treating hepatic injury.
葛花主要异黄酮成分之一的葛花苷，已针对其对小鼠乙醇诱导的中毒以及对包括高血糖症在内的肝损伤的影响进行了研究。葛花苷降低了与乙醇给药相关的死亡率。在100和200毫克/千克的剂量下，葛花苷的效果显著。相同剂量的葛花苷可防止血清谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶活性升高。在200毫克/千克的剂量下，它还能抵消乙醇诱导的血糖水平升高。这些结果表明，葛花苷可能有助于对抗酒精的影响，并且可能对治疗肝损伤有效。
