Lataye R, Campo P
Institut National de Recherche et de Sécurité (I.N.R.S.), Vandoeuvre, France.
Neurotoxicol Teratol. 1997 Sep-Oct;19(5):373-82. doi: 10.1016/s0892-0362(97)00049-4.
To study the combined effects of noise and toluene on auditory function, three experimental groups of Long-Evans adult rats were used. The first group was exposed to toluene (2000 ppm, 6 h/day, 5 days/week, 4 weeks), the second group to an octave band of noise centered at 8 kHz (92 dB SPL), and the last group to a simultaneous exposure to toluene and noise. Auditory function was tested by recording brainstem (inferior colliculus) auditory-evoked potentials. The auditory deficit induced by the combined exposure exceeded the summated losses caused by toluene alone and by noise alone within the range (2-32 kHz) of test frequencies. The nature of the cochlear damage induced by noise alone (injured stereocilia) or by toluene alone (outer hair cells loss) is different.
为研究噪声和甲苯对听觉功能的联合影响，使用了三组成年Long-Evans大鼠进行实验。第一组暴露于甲苯（2000 ppm，每天6小时，每周5天，共4周），第二组暴露于以8 kHz为中心的倍频程噪声（92 dB SPL），最后一组同时暴露于甲苯和噪声。通过记录脑干（下丘）听觉诱发电位来测试听觉功能。在测试频率范围（2 - 32 kHz）内，联合暴露引起的听觉缺陷超过了单独甲苯和单独噪声所造成的损失之和。单独噪声（静纤毛损伤）或单独甲苯（外毛细胞损失）引起的耳蜗损伤性质不同。
