头孢菌素与氨基糖苷类药物在实验性肠球菌心内膜炎中的协同作用。
Cephalosporin-aminoglycoside synergism in experimental enterococcal endocarditis.
作者信息
Weinstein A J, Lentnek A L
出版信息
Antimicrob Agents Chemother. 1976 Jun;9(6):983-7. doi: 10.1128/AAC.9.6.983.
Abstract
Despite in vitro demonstrations of synergism against enterococci, combinations of cephalosporin and aminoglycoside antibodies have been ineffective in the therapy of enterococcal endocarditis. Penicillin-gentamicin, cephalothin-gentamicin, and cefazolin-gentamicin were used to treat enterococcal endocarditis in rabbits. A direct relation was observed between the rate of cure and the degree by which the peak serum concentration of penicillin and the cephalosporins exceeded the minimal inhibitory concentration of the enterococcus. Thus, cephalosporin doses which produce serum concentrations which exceed the minimal inhibitory concentration of the enterococcus by several orders of magnitude may, in combination with aminoglycosides, be effective in treating human enterococcal endocarditis.
摘要
尽管在体外实验中已证明头孢菌素和氨基糖苷类抗生素联合使用对肠球菌有协同作用，但在治疗肠球菌性心内膜炎时，二者联合使用却效果不佳。曾用青霉素-庆大霉素、头孢噻吩-庆大霉素和头孢唑林-庆大霉素治疗兔的肠球菌性心内膜炎。结果发现治愈率与青霉素和头孢菌素的血清峰值浓度超过肠球菌最低抑菌浓度的程度直接相关。因此，能使血清浓度超过肠球菌最低抑菌浓度几个数量级的头孢菌素剂量，与氨基糖苷类抗生素联合使用时，可能对治疗人类肠球菌性心内膜炎有效。
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