蛋白质结合对青霉素与庆大霉素联合抗肠球菌活性的影响。
Effect of protein binding on the activity of penicillins in combination with gentamicin against enterococci.
作者信息
Glew R H, Moellering R C
出版信息
Antimicrob Agents Chemother. 1979 Jan;15(1):87-92. doi: 10.1128/AAC.15.1.87.
Abstract
To assess the effect of protein binding by human serum on the synergistic interaction of penicillins with gentamicin, time-kill curves were determined for four penicillins alone and in combination with gentamicin against 10 blood isolates of enterococci. Killing curves demonstrated synergism with penicillin G plus gentamicin against all 10 strains in either broth or 50% human serum. In broth the combinations of nafcillin plus gentamicin and oxacillin plus gentamicin were synergistic against 10 of 10 strains and 4 of 10 strains, respectively. However, in serum, nafcillin plus gentamicin was synergistically bactericidal against only two strains and oxacillin plus gentamicin against none. Methicillin plus gentamicin was synergistic against none of the enterococci in either medium. Thus, the semisynthetic, penicillinase-resistant penicillins are unlikely to be effective in the therapy of patients with enterococcal endocarditis.
摘要
为评估人血清蛋白结合对青霉素与庆大霉素协同相互作用的影响，测定了四种青霉素单独及与庆大霉素联合作用于10株肠球菌血培养分离株的时间杀菌曲线。杀菌曲线表明，在肉汤或50%人血清中，青霉素G加庆大霉素对所有10株菌株均显示协同作用。在肉汤中，萘夫西林加庆大霉素及苯唑西林加庆大霉素的联合用药分别对10株中的10株及10株中的4株有协同作用。然而，在血清中，萘夫西林加庆大霉素仅对两株有协同杀菌作用，苯唑西林加庆大霉素则无协同杀菌作用。在两种培养基中，甲氧西林加庆大霉素对肠球菌均无协同作用。因此，半合成的、耐青霉素酶的青霉素不太可能有效治疗肠球菌性心内膜炎患者。
相似文献
1
Effect of protein binding on the activity of penicillins in combination with gentamicin against enterococci.蛋白质结合对青霉素与庆大霉素联合抗肠球菌活性的影响。
Antimicrob Agents Chemother. 1979 Jan;15(1):87-92. doi: 10.1128/AAC.15.1.87.
2
Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci.萘夫西林、苯唑西林和甲氧西林联合庆大霉素及妥布霉素对肠球菌的体外比较活性
Antimicrob Agents Chemother. 1977 Jan;11(1):88-91. doi: 10.1128/AAC.11.1.88.
3
Comparative bactericidal activity of penicillin-netilmicin and penicillin-gentamicin against enterococci.青霉素-奈替米星与青霉素-庆大霉素对肠球菌的杀菌活性比较
J Antimicrob Chemother. 1986 May;17(5):585-91. doi: 10.1093/jac/17.5.585.
4
Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against.萘夫西林、苯唑西林和甲氧西林与庆大霉素联合使用时的比较协同活性。
Antimicrob Agents Chemother. 1975 Jun;7(6):828-32. doi: 10.1128/AAC.7.6.828.
5
Penicillinase-resistant penicillins plus gentamicin in experimental enterococcal endocarditis.耐青霉素酶青霉素加庆大霉素用于实验性肠球菌性心内膜炎
Antimicrob Agents Chemother. 1977 Oct;12(4):484-9. doi: 10.1128/AAC.12.4.484.
6
In vitro activity of sisomicin and netilmicin alone and in combination with nafcillin, oxacillin and methicillin against enterococci.西索米星和奈替米星单独及与萘夫西林、苯唑西林和甲氧西林联合应用对肠球菌的体外活性。
Chemotherapy. 1978;24(4):236-9. doi: 10.1159/000237787.
7
Synergy of penicillin and decreasing concentration of aminoglycosides against enterococci from patients with infective endocarditis.青霉素与降低浓度的氨基糖苷类药物对感染性心内膜炎患者肠球菌的协同作用。
Antimicrob Agents Chemother. 1980 Dec;18(6):944-7. doi: 10.1128/AAC.18.6.944.
8
Early synergistic interaction between semisynthetic penicillins and aminoglycosidic aminocyclitols against Enterobacteriaceae.半合成青霉素与氨基糖苷类氨基环醇类药物对肠杆菌科细菌的早期协同相互作用。
Antimicrob Agents Chemother. 1983 Jun;23(6):902-6. doi: 10.1128/AAC.23.6.902.
9
Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin.青霉素与妥布霉素对肠球菌的协同作用：与青霉素和庆大霉素的比较。
Antimicrob Agents Chemother. 1973 Apr;3(4):526-9. doi: 10.1128/AAC.3.4.526.
10
Bactericidal activity of combinations of gentamicin with penicillin or clindamycin against Streptococcus mutans.庆大霉素与青霉素或克林霉素联合使用对变形链球菌的杀菌活性。
Antimicrob Agents Chemother. 1975 Mar;7(3):333-5. doi: 10.1128/AAC.7.3.333.
引用本文的文献
1
Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.在THP-1巨噬细胞模型中对抗生素针对金黄色葡萄球菌的细胞内活性进行药效学评估。
Antimicrob Agents Chemother. 2006 Mar;50(3):841-51. doi: 10.1128/AAC.50.3.841-851.2006.
2
Susceptibility of enterococci and Listeria monocytogenes to N-Formimidoyl thienamycin alone and in combination with an aminoglycoside.肠球菌和单核细胞增生李斯特菌对单独使用及与氨基糖苷类联合使用的N-亚胺基噻烯霉素的敏感性。
Antimicrob Agents Chemother. 1981 May;19(5):789-93. doi: 10.1128/AAC.19.5.789.
3
In vitro activity of Sch 34343 against enterococci and other gram-positive bacteria.Sch 34343对肠球菌及其他革兰氏阳性菌的体外活性。
Antimicrob Agents Chemother. 1985 Jan;27(1):28-32. doi: 10.1128/AAC.27.1.28.
4
In vitro activity of BMY-28100, a new oral cephalosporin.新型口服头孢菌素BMY - 28100的体外活性
Antimicrob Agents Chemother. 1987 Apr;31(4):653-6. doi: 10.1128/AAC.31.4.653.
5
Antibiotic combinations: should they be tested?抗生素联合使用：是否应该进行检测？
Clin Microbiol Rev. 1988 Apr;1(2):139-56. doi: 10.1128/CMR.1.2.139.
6
Serum bactericidal test.血清杀菌试验
Clin Microbiol Rev. 1988 Jan;1(1):19-26. doi: 10.1128/CMR.1.1.19.
7
The life and times of the Enterococcus.肠球菌的生存与时代
Clin Microbiol Rev. 1990 Jan;3(1):46-65. doi: 10.1128/CMR.3.1.46.
8
The epidemiology of enterococci.肠球菌的流行病学
Eur J Clin Microbiol Infect Dis. 1990 Feb;9(2):80-9. doi: 10.1007/BF01963631.
本文引用的文献
1
The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in Vitro.青霉素与链霉素或氯霉素对肠球菌的体外联合作用
Science. 1950 Mar 10;111(2880):254-6. doi: 10.1126/science.111.2880.254.
2
The Relation of Protein Binding to the Pharmacology and Antibacterial Activity of Penicillins X, G, Dihydro F, and K.蛋白质结合与青霉素X、G、二氢F和K的药理学及抗菌活性的关系
J Bacteriol. 1947 May;53(5):581-95. doi: 10.1128/jb.53.5.581-595.1947.
3
Use of autoclaved extracts of hemolytic streptococci for serological grouping.使用溶血性链球菌的高压灭菌提取物进行血清学分型。
Stanford Med Bull. 1955 May;13(2):290-1.
4
THE GROUP D STREPTOCOCCI.D群链球菌
Bacteriol Rev. 1964 Sep;28(3):330-66. doi: 10.1128/br.28.3.330-366.1964.
5
Acute alcoholic hepatitis. A clinical study of fifty cases.急性酒精性肝炎。五十例临床研究。
Arch Intern Med. 1963 Jul;112:67-78. doi: 10.1001/archinte.1963.03860010113013.
6
Enterococcal endocarditis. Report of nineteen cases with long-term follow-up data.肠球菌性心内膜炎。19例长期随访数据报告。
N Engl J Med. 1961 Feb 9;264:257-64. doi: 10.1056/NEJM196102092640601.
7
Antibiotic synergism and antagonism; an assessment of the problem.抗生素协同作用与拮抗作用；问题评估
Pharmacol Rev. 1953 Jun;5(2):175-92.
8
A rapid, modified ultrafiltration method for determining serum protein binding and its application to new penicillins.
J Lab Clin Med. 1965 Nov;66(5):721-32.
9
Enterococcal endocarditis. An analysis of 38 patients observed at the New York Hospital-Cornell Medical Center.肠球菌性心内膜炎。对纽约医院-康奈尔医学中心观察的38例患者的分析。
Arch Intern Med. 1970 Feb;125(2):258-64. doi: 10.1001/archinte.125.2.258.
10
Evaluation of a new differential test for enterococci in the clinical laboratory.临床实验室中一种新型肠球菌鉴别试验的评估
J Med Microbiol. 1970 May;3(2):227-31. doi: 10.1099/00222615-3-2-227.
Zotero 插件