Van Dijck P, van de Voorde H
Appl Environ Microbiol. 1976 Mar;31(3):332-6. doi: 10.1128/aem.31.3.332-336.1976.
The sensitivity of different microorganisms, considered as typical representatives of the microflora of soil and water, was established to evaluate the influence of the nonmedical use of antimicrobial agents on bacterial ecology. Only seven strains, six chemoorganotrophs and one chemolithotroph, could be considered as relatively sensitive to the 21 antimicrobial compounds tested. The other 29 microorganisms may be regarded as resistant to most antimicrobial agents. Streptomyces were sensitive to high concentrations of active substances. Broad-spectrum antibiotics showed an effect on environmental bacteria similar to that on human pathogens. Cephalothin stimulated the growth of a Chlorella sp. From these experiments, it appears that spilled antimicrobial agents have little chance of causing an alteration in the microbial ecology.
为评估抗菌剂非医疗用途对细菌生态的影响，对被视为土壤和水微生物群落典型代表的不同微生物的敏感性进行了测定。在所测试的21种抗菌化合物中，只有7株菌（6株化能有机营养菌和1株化能无机营养菌）可被认为对其相对敏感。其他29种微生物可能被视为对大多数抗菌剂具有抗性。链霉菌对高浓度活性物质敏感。广谱抗生素对环境细菌的作用与对人类病原体的作用相似。头孢噻吩刺激了一种小球藻属（Chlorella sp.）的生长。从这些实验看来，泄漏的抗菌剂几乎没有机会引起微生物生态的改变。
