从一例原发性阿米巴脑膜脑炎病例中分离出的一种耐格里属变形虫对两性霉素B的敏感性。
Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis.
作者信息
Carter R F
出版信息
J Clin Pathol. 1969 Jul;22(4):470-4. doi: 10.1136/jcp.22.4.470.
Abstract
An amoeba of the genus Naegleria causing fatal meningoencephalitis in a human subject has been investigated for its sensitivity to several drugs. Penicillin, sulphadiazine, chloramphenicol, oxytetracycline hydrochloride, streptomycin, methotrexate, emetine, quinine, and metronidazole had no effect on the organism in vitro at levels in excess of those likely to be attained therapeutically in the brain. Amphotericin B was highly amoebicidal in vitro and protected mice from infection with the organism. Used in high dosage by the intraventricular as well as the intravenous route, this drug might be successful in the treatment of further cases of primary amoebic meningoencephalitis.
摘要
对一株在人类受试者中引起致命性脑膜脑炎的耐格里属阿米巴原虫进行了几种药物敏感性研究。青霉素、磺胺嘧啶、氯霉素、盐酸土霉素、链霉素、甲氨蝶呤、依米丁、奎宁和甲硝唑在体外浓度超过脑内治疗可能达到的水平时，对该病原体无作用。两性霉素B在体外具有高度杀阿米巴原虫活性，并可保护小鼠免受该病原体感染。通过脑室内和静脉途径高剂量使用该药物，可能成功治疗更多原发性阿米巴脑膜脑炎病例。
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Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis.从一例原发性阿米巴脑膜脑炎病例中分离出的一种耐格里属变形虫对两性霉素B的敏感性。
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