[墨西哥复发性自然流产夫妇的免疫遗传学研究]
[Immunogenetic study in Mexican couples with recurrent spontaneous abortions].
作者信息
Silva B, Yamamoto-Furusho J K, Grether P, Vargas-Alarcón G, Kofman S, Granados J
机构信息
Departamento de Genética, Hospital General de México, SS, México, D.F.
出版信息
Rev Invest Clin. 1997 May-Jun;49(3):183-7.
AIM
To study the HLA markers in Mexican couples who have suffered three or more spontaneous abortions.
DESIGN
The study included 24 couples with recurrent abortions and 32 with normal fertility.
METHOD
HLA class I (A, B, C) and class II (DR, DQ) typing was done with a standard microlymphocytoxity test. The intergroup differences were evaluated by chi-square and the Fisher exact test.
RESULTS
The frequency of the MHC markers in the males and females of couples with abortions were not significantly different from those in fertile couples. However, the abortion couples shared class I antigens more often than expected from random mating as compared to fertile couples, specially in the HLA-B locus. We also found a significantly decreased frequency of the HLA-B7 antigen in males belonging to the abortion group.
CONCLUSION
These results suggest that HLA-B antigens may be markers for genes related to pregnancy outcome in Mexicans.
目的
研究经历过三次或更多次自然流产的墨西哥夫妇的人类白细胞抗原（HLA）标记物。
设计
该研究纳入了24对复发性流产夫妇和32对生育能力正常的夫妇。
方法
采用标准微量淋巴细胞毒性试验进行HLA I类（A、B、C）和II类（DR、DQ）分型。通过卡方检验和费舍尔精确检验评估组间差异。
结果
流产夫妇中男性和女性的主要组织相容性复合体（MHC）标记物频率与生育能力正常的夫妇相比无显著差异。然而，与生育能力正常的夫妇相比，流产夫妇共享I类抗原的频率高于随机交配预期的频率，特别是在HLA - B位点。我们还发现流产组男性中HLA - B7抗原的频率显著降低。
结论
这些结果表明，HLA - B抗原可能是墨西哥人妊娠结局相关基因的标记物。
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