Balasch J, Pastor M, Martorell J, Vanrell J A, Cuturi C, González-Merlo J
Int J Fertil. 1986 Jul-Aug;31(3):213-7.
Ten couples with a history of at least three (mean 3.8) consecutive spontaneous abortions of unknown etiology and 57 normal fertile couples (means 2.6 children) were tested for HLA antigens. The frequencies of shared HLA-A, -B and -DR antigens among members of the couples were similar in both groups. Our results, as well as analysis of the data in the literature, contradict HLA antigens sharing between parents as a determinant of recurrent spontaneous abortion.
对十对有至少三次(平均3.8次)不明病因连续自然流产史的夫妇以及57对正常可育夫妇(平均育有2.6个孩子)进行了HLA抗原检测。两组夫妇成员之间共有的HLA - A、 - B和 - DR抗原频率相似。我们的研究结果以及对文献数据的分析均与父母之间HLA抗原共享作为复发性自然流产的决定因素这一观点相矛盾。