Levine P H, McVerry B A, Segelman A E, Cranford C M, Zimbler S
Arch Intern Med. 1976 Jul;136(7):792-4.
One hundred hemophiliacs were examined at a formal comprehensive health care clinic. Sixty-eight percent had abnormal results of liver function tests, and 26% had spleens that were palpable. Measurement of range of motion of knees, ankles, hips, shoulders, and elbows showed a high incidence of hemophilic arthropathy and established a precise baseline by which to judge efficacy of therapy. Results of dental examination disclosed a 14% incidence of multiple severe caries, which is an incidence lower than that of the population as a whole. Examples of inadequate dosage of replacement therapy (16%) and chronic delay in application of self-therapy (14%) were discovered. An 8% incidence of hypertension was noted; prior experience suggests that the combination of hypertension and hemophilia may be lethal. Other clinical and laboratory data also illustrate the importance of a periodic, formally structured, comprehensive examination of hemophiliacs.
在一家正规的综合医疗诊所对100名血友病患者进行了检查。68%的患者肝功能测试结果异常，26%的患者脾脏可触及。对膝盖、脚踝、臀部、肩膀和肘部的活动范围进行测量显示，血友病性关节病的发病率很高，并建立了一个精确的基线来判断治疗效果。牙科检查结果显示，多发性严重龋齿的发病率为14%，低于整个人口的发病率。发现了替代疗法剂量不足（16%）和自我治疗长期延误（14%）的例子。注意到高血压的发病率为8%；以往经验表明，高血压与血友病并存可能是致命的。其他临床和实验室数据也说明了对血友病患者进行定期、正式结构化的全面检查的重要性。
