Gittleman-Klein R, Klein D F
Arch Gen Psychiatry. 1976 Jun;33(6):655-64. doi: 10.1001/archpsyc.1976.01770060003001.
Sixty-one children of average intelligence with appreciable learning lags, but no behaviour disorders, received placedo or methylphenidate hydrochloride for a 12-week period. Methylphenidate was instrumental in improving performance on many psychological tests, but did not affect performance on standardized achievement tests. None of the patient characteristics investigated was stringly predictive of drug effect. Methylphenidate seems to have a specific effect on visualmotor processes, which in turn positively affect performance tasks, but not verbal tasks. Under the conditions of this study, methylphenidate treatment alone did not emerge as a useful agent for the amelioration of reading performance, although the data provide evidence for stimulation effects on children's cognitive functions.
61名智力中等但有明显学习滞后问题且无行为障碍的儿童，接受了为期12周的普拉西多或盐酸哌甲酯治疗。盐酸哌甲酯有助于提高多项心理测试的成绩，但对标准化成就测试的成绩没有影响。所研究的患者特征均不能强烈预测药物疗效。盐酸哌甲酯似乎对视觉运动过程有特定作用，这反过来又对执行任务的表现有积极影响，但对言语任务没有影响。在本研究条件下，单独使用盐酸哌甲酯治疗并未成为改善阅读成绩的有效药物，尽管数据为其对儿童认知功能的刺激作用提供了证据。
