基于结构研究对分支酸变位酶催化机制的新见解。
New insight into the catalytic mechanism of chorismate mutases from structural studies.
作者信息
Lee A Y, Stewart J D, Clardy J, Ganem B
机构信息
Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
出版信息
Chem Biol. 1995 Apr;2(4):195-203. doi: 10.1016/1074-5521(95)90269-4.
PMID:9383421
Abstract
Chorismate mutase catalyzes the rearrangement of chorismic acid to prephenic acid, which is the first committed step in the biosynthesis of aromatic amino acids. Its catalytic mechanism has been much studied, but is poorly understood. Recent structural information on enzymes from two species, and on an antibody that catalyzes the same reaction, has shed new light on this topic.
摘要
分支酸变位酶催化分支酸重排为预苯酸，这是芳香族氨基酸生物合成中的第一个关键步骤。其催化机制已得到大量研究，但仍了解甚少。最近关于两种物种的酶以及一种催化相同反应的抗体的结构信息，为这一课题带来了新的启示。
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