沙门氏菌感染会增加猪血清中抗菌肽的浓度。
Salmonella infection increases porcine antibacterial peptide concentrations in serum.
作者信息
Zhang G, Ross C R, Dritz S S, Nietfeld J C, Blecha F
机构信息
Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA.
出版信息
Clin Diagn Lab Immunol. 1997 Nov;4(6):774-7. doi: 10.1128/cdli.4.6.774-777.1997.
Abstract
PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.
摘要
PR-39是一种参与宿主防御和炎症反应的多功能中性粒细胞肽。为了研究PR-39在猪霍乱沙门氏菌感染中的作用，开发了一种PR-39酶免疫测定法。攻毒前血清中PR-39的浓度为13.6±1.9 ng/ml，感染后10至14天增加了三倍（P<0.01）。外周血中性粒细胞计数与血清中PR-39浓度的变化平行，感染后4周均恢复到基础值。这些发现表明，血清PR-39的浓度反映了这种抗菌肽在宿主对猪霍乱沙门氏菌感染反应中的作用。
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