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Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide.一种源自富含脯氨酸-精氨酸的中性粒细胞抗菌肽PR-39的合成肽（PR-26）的抗菌活性。
Antimicrob Agents Chemother. 1996 Jan;40(1):115-21. doi: 10.1128/AAC.40.1.115.
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Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine.从嗜中性粒细胞中鉴定出一种富含脯氨酸和精氨酸的抗菌肽，它类似于小肠抗菌肽PR-39。
J Leukoc Biol. 1994 Dec;56(6):807-11. doi: 10.1002/jlb.56.6.807.
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Chemoattractant properties of PR-39, a neutrophil antibacterial peptide.中性粒细胞抗菌肽PR-39的趋化活性
J Leukoc Biol. 1997 May;61(5):624-9. doi: 10.1002/jlb.61.5.624.
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Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine.猪肠道中杀菌肽和富含脯氨酸-精氨酸的肽的合成及抗菌作用
J Pept Res. 1997 Jan;49(1):59-66. doi: 10.1111/j.1399-3011.1997.tb01121.x.
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Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.PR-39的氨基酸序列。从猪肠道中分离出富含脯氨酸-精氨酸的抗菌肽家族的一个新成员。
Eur J Biochem. 1991 Dec 18;202(3):849-54. doi: 10.1111/j.1432-1033.1991.tb16442.x.
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Salmonella infection increases porcine antibacterial peptide concentrations in serum.沙门氏菌感染会增加猪血清中抗菌肽的浓度。
Clin Diagn Lab Immunol. 1997 Nov;4(6):774-7. doi: 10.1128/cdli.4.6.774-777.1997.
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PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6014-8. doi: 10.1073/pnas.93.12.6014.
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Antimicrobial and Immunomodulatory Activity of PMAP-23 Derived Peptides.PMAP-23衍生肽的抗菌和免疫调节活性。
Protein Pept Lett. 2017;24(7):609-616. doi: 10.2174/0929866524666170428150925.
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PR-39, a proline/arginine-rich antimicrobial peptide, prevents postischemic microvascular dysfunction.
Am J Physiol. 1999 Sep;277(3):H1007-13. doi: 10.1152/ajpheart.1999.277.3.H1007.
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Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells.天蚕素A（1-8）-蛙皮素2（1-12）（一种合成抗菌肽）的铰链区对脂质体、细菌和肿瘤细胞的影响。
Biochim Biophys Acta. 2000 Feb 15;1463(2):209-18. doi: 10.1016/s0005-2736(99)00210-2.
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Advances in Antimicrobial Peptides: Mechanisms, Design Innovations, and Biomedical Potential.抗菌肽的进展：作用机制、设计创新及生物医学潜力
Molecules. 2025 Mar 29;30(7):1529. doi: 10.3390/molecules30071529.
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Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.抗菌肽与非直接抗菌阳离子肽的协同协作。
Nat Commun. 2024 Aug 25;15(1):7319. doi: 10.1038/s41467-024-51730-x.
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Anti-Cancer Peptides: Status and Future Prospects.抗癌肽：现状与未来展望。
Molecules. 2023 Jan 23;28(3):1148. doi: 10.3390/molecules28031148.
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Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain.探讨重组大肠杆菌菌株对防御素抗菌活性的影响：BL21 与 Origami 菌株。
Microb Cell Fact. 2022 May 9;21(1):77. doi: 10.1186/s12934-022-01803-7.
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Synergistic Action of Antimicrobial Lung Proteins against .抗菌肺蛋白对 … 的协同作用。
Int J Mol Sci. 2021 Oct 15;22(20):11146. doi: 10.3390/ijms222011146.
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Antimicrobial Peptides and Proteins: From Nature's Reservoir to the Laboratory and Beyond.抗菌肽与蛋白质：从自然界宝库到实验室及其他领域
Front Chem. 2021 Jun 18;9:691532. doi: 10.3389/fchem.2021.691532. eCollection 2021.
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Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs.山羊抗菌肽作为开发新型抗菌和抗肿瘤药物的有前途的工具。
Front Cell Infect Microbiol. 2020 Oct 19;10:552905. doi: 10.3389/fcimb.2020.552905. eCollection 2020.
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Tryptophan-Rich and Proline-Rich Antimicrobial Peptides.富含色氨酸和脯氨酸的抗菌肽。
Molecules. 2018 Apr 2;23(4):815. doi: 10.3390/molecules23040815.
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Revealing the sequence of interactions of PuroA peptide with Candida albicans cells by live-cell imaging.通过活细胞成像揭示 PuroA 肽与白色念珠菌细胞的相互作用序列。
Sci Rep. 2017 Mar 2;7:43542. doi: 10.1038/srep43542.
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Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens.从鸡血红蛋白中分离出的肽的抗菌活性及安全性评价
BMC Microbiol. 2016 Dec 5;16(1):287. doi: 10.1186/s12866-016-0904-3.
本文引用的文献
1
Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine.猪肠道来源的两种抗菌肽——天蚕素P1和PR-39对大肠杆菌的作用机制
Infect Immun. 1993 Jul;61(7):2978-84. doi: 10.1128/iai.61.7.2978-2984.1993.
2
Defensins: antimicrobial and cytotoxic peptides of mammalian cells.防御素：哺乳动物细胞的抗菌和细胞毒性肽。
Annu Rev Immunol. 1993;11:105-28. doi: 10.1146/annurev.iy.11.040193.000541.
3
Characterization of bovine neutrophil antibacterial polypeptides which bind to Escherichia coli.与大肠杆菌结合的牛中性粒细胞抗菌多肽的特性分析
Infect Immun. 1993 Mar;61(3):966-9. doi: 10.1128/iai.61.3.966-969.1993.
4
Medical relevance of low concentrations of antibiotics.
J Antimicrob Chemother. 1993 May;31 Suppl D:137-48. doi: 10.1093/jac/31.suppl_d.137.
5
The post-antibiotic effect.抗生素后效应
J Antimicrob Chemother. 1993 Oct;32(4):519-37. doi: 10.1093/jac/32.4.519.
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Effects of multiplicity of infection, bacterial protein synthesis, and growth phase on adhesion to and invasion of human cell lines by Salmonella typhimurium.多重感染、细菌蛋白质合成及生长阶段对鼠伤寒沙门氏菌黏附及侵入人细胞系的影响。
Infect Immun. 1993 Dec;61(12):5013-20. doi: 10.1128/iai.61.12.5013-5020.1993.
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Ubiquitous natural antibiotics.普遍存在的天然抗生素。
Science. 1994 Apr 15;264(5157):373-4. doi: 10.1126/science.8153623.
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A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria.一类胞质外蛋白家族，可使大分子穿过革兰氏阴性菌的外膜。
J Bacteriol. 1994 Jul;176(13):3825-31. doi: 10.1128/jb.176.13.3825-3831.1994.
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Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine.从嗜中性粒细胞中鉴定出一种富含脯氨酸和精氨酸的抗菌肽，它类似于小肠抗菌肽PR-39。
J Leukoc Biol. 1994 Dec;56(6):807-11. doi: 10.1002/jlb.56.6.807.
10
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.Syndecans是细胞表面硫酸乙酰肝素蛋白聚糖，由伤口处富含脯氨酸的抗菌肽诱导产生。
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11035-9. doi: 10.1073/pnas.91.23.11035.
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