Hoshi M, Yoshida K, Shimazaki K, Sasaki H, Otani M, Kawase T
Department of Neurosurgery, School of Medicine Keio University, Tokyo, Japan.
Brain Tumor Pathol. 1997;14(1):47-51. doi: 10.1007/BF02478868.
Although low-grade astrocytomas are histologically benign, some of them recur frequently. We retrospectively investigated the relationship between MIB-1 staining index (SI) and recurrence in 47 low-grade astrocytomas that were treated in Keio University Hospital from 1981 to 1991. We found a correlation between SI and recurrence. MIB-1 SIs recurrent low-grade astrocytomas have been shown to be almost similar to those of astrocytoma grade 3. We concluded that it was very important to examine MIB-1 SI in all astrocytomas especially in low-grade astrocytomas, because MIB-1 SI is one of the factors from which we could predict-recurrence and decide whether radiotherapy or chemotherapy should be performed.
