组织工程与Apligraf（一种人工皮肤替代品）的研发。

Tissue engineering and the development of Apligraf, a human skin equivalent.

作者信息

Eaglstein W H, Falanga V

机构信息

Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida, USA.

出版信息

Clin Ther. 1997 Sep-Oct;19(5):894-905. doi: 10.1016/s0149-2918(97)80043-4.

DOI:10.1016/s0149-2918(97)80043-4

PMID:9385478

Abstract

In recent years, skin grafting has evolved from the initial autograft and allograft preparations to biosynthetic and tissue-engineered living skin replacements. This review details the pioneering work of numerous investigators that led to the following precursors of tissue-engineered skin replacement: cultured autologous keratinocyte grafts, cultured allogeneic keratinocyte grafts, autologous/allogeneic composites, acellular collagen matrices, and cellular matrices. It also discusses the rationale for the development of the newer products and describes the technical advances leading to the development of Apligraf, a tissue-engineered human skin product.

摘要

近年来，皮肤移植已从最初的自体移植和异体移植发展到生物合成和组织工程化的活性皮肤替代物。本文综述了众多研究者的开创性工作，这些工作催生了以下组织工程化皮肤替代物的前身：培养的自体角质形成细胞移植、培养的同种异体角质形成细胞移植、自体/同种异体复合物、脱细胞胶原基质和细胞基质。本文还讨论了更新产品的开发原理，并描述了促成组织工程化人类皮肤产品Apligraf开发的技术进展。