基于胶原蛋白和透明质酸的水凝胶及其生物医学应用。
Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.
作者信息
Xu Qinghua, Torres Jessica E, Hakim Mazin, Babiak Paulina M, Pal Pallabi, Battistoni Carly M, Nguyen Michael, Panitch Alyssa, Solorio Luis, Liu Julie C
机构信息
Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
Mater Sci Eng R Rep. 2021 Oct;146. doi: 10.1016/j.mser.2021.100641. Epub 2021 Jul 30.
Abstract
Hydrogels have been widely investigated in biomedical fields due to their similar physical and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid (HA) are the main components of the ECM in many tissues. As a result, hydrogels prepared from collagen and HA hold inherent advantages in mimicking the structure and function of the native ECM. Numerous studies have focused on the development of collagen and HA hydrogels and their biomedical applications. In this extensive review, we provide a summary and analysis of the sources, features, and modifications of collagen and HA. Specifically, we highlight the fabrication, properties, and potential biomedical applications as well as promising commercialization of hydrogels based on these two natural polymers.
摘要
由于水凝胶在物理和生化特性上与细胞外基质（ECM）相似，因此在生物医学领域得到了广泛研究。胶原蛋白和透明质酸（HA）是许多组织中细胞外基质的主要成分。因此，由胶原蛋白和透明质酸制备的水凝胶在模拟天然细胞外基质的结构和功能方面具有内在优势。许多研究都集中在胶原蛋白和透明质酸水凝胶的开发及其生物医学应用上。在这篇全面的综述中，我们对胶原蛋白和透明质酸的来源、特性及修饰进行了总结和分析。具体而言，我们重点介绍了基于这两种天然聚合物的水凝胶的制备、性质、潜在生物医学应用以及有前景的商业化情况。
相似文献
1
Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.基于胶原蛋白和透明质酸的水凝胶及其生物医学应用。
Mater Sci Eng R Rep. 2021 Oct;146. doi: 10.1016/j.mser.2021.100641. Epub 2021 Jul 30.
2
Hyaluronic acid-fibrin interpenetrating double network hydrogel prepared in situ by orthogonal disulfide cross-linking reaction for biomedical applications.通过正交二硫键交联反应原位制备用于生物医学应用的透明质酸-纤维蛋白互穿双网络水凝胶。
Acta Biomater. 2016 Jul 1;38:23-32. doi: 10.1016/j.actbio.2016.04.041. Epub 2016 Apr 28.
3
Chondroitin sulfate, dermatan sulfate, and hyaluronic acid differentially modify the biophysical properties of collagen-based hydrogels.硫酸软骨素、硫酸皮肤素和透明质酸可改变基于胶原蛋白的水凝胶的生物物理特性。
Acta Biomater. 2024 Jan 15;174:116-126. doi: 10.1016/j.actbio.2023.12.018. Epub 2023 Dec 14.
4
Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture.应激放松型透明质酸-胶原蛋白水凝胶促进 3D 细胞培养中的细胞铺展、纤维重塑和焦点黏附形成。
Biomaterials. 2018 Feb;154:213-222. doi: 10.1016/j.biomaterials.2017.11.004. Epub 2017 Nov 6.
5
Photopatterned collagen-hyaluronic acid interpenetrating polymer network hydrogels.光图案化的胶原-透明质酸互穿聚合物网络水凝胶
Acta Biomater. 2009 Sep;5(7):2385-97. doi: 10.1016/j.actbio.2009.05.004. Epub 2009 May 13.
6
Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications.动态共价交联透明质酸水凝胶和纳米材料在生物医学中的应用。
Biomater Sci. 2022 Nov 8;10(22):6399-6412. doi: 10.1039/d2bm01154a.
7
Supramolecular hydrogel networks formed by molecular recognition of collagen and a peptide grafted to hyaluronic acid.由胶原蛋白和接枝到透明质酸上的肽的分子识别形成的超分子水凝胶网络。
Acta Biomater. 2016 Jul 1;38:1-10. doi: 10.1016/j.actbio.2016.04.018. Epub 2016 Apr 21.
8
Double - network hydrogel based on exopolysaccharides as a biomimetic extracellular matrix to augment articular cartilage regeneration.基于胞外多糖的双网络水凝胶作为仿生细胞外基质增强关节软骨再生。
Acta Biomater. 2022 Oct 15;152:124-143. doi: 10.1016/j.actbio.2022.08.062. Epub 2022 Aug 31.
9
Characteristics of Collagen-Rich Extracellular Matrix Hydrogels and Their Functionalization with Poly(ethylene glycol) Derivatives for Enhanced Biomedical Applications: A Review.富含胶原蛋白的细胞外基质水凝胶的特性及其用聚乙二醇衍生物功能化以增强生物医学应用：综述
ACS Appl Bio Mater. 2018 Nov 19;1(5):1215-1228. doi: 10.1021/acsabm.8b00282. Epub 2018 Oct 24.
10
Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels.透明质酸-明胶杂化水凝胶的合成与表征。
Biomacromolecules. 2013 Apr 8;14(4):1085-92. doi: 10.1021/bm3019856. Epub 2013 Mar 28.
引用本文的文献
1
Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model.使用组织工程化动脉粥样硬化帽模型研究微钙化大小和体积对胶原基质及组织力学的影响。
Front Cardiovasc Med. 2025 Aug 20;12:1629285. doi: 10.3389/fcvm.2025.1629285. eCollection 2025.
2
Advances in hyaluronic acid hydrogel for meniscus repair.用于半月板修复的透明质酸水凝胶的研究进展。
Front Bioeng Biotechnol. 2025 Jul 21;13:1639034. doi: 10.3389/fbioe.2025.1639034. eCollection 2025.
3
Photo-Cross-Linked Porous Hybrid Networks Based on Insoluble Collagen and Poly(trimethylene carbonate).基于不溶性胶原蛋白和聚碳酸三亚甲酯的光交联多孔混合网络
Biomacromolecules. 2025 Aug 11;26(8):5399-5408. doi: 10.1021/acs.biomac.5c00971. Epub 2025 Jul 29.
4
Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation.发育中的肢体间充质中透明质酸合酶2的基因缺陷会损害出生后滑膜关节的形成。
Biomedicines. 2025 May 28;13(6):1324. doi: 10.3390/biomedicines13061324.
5
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering.术后粘连屏障及子宫组织工程中的生物材料
Gels. 2025 Jun 9;11(6):441. doi: 10.3390/gels11060441.
6
Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics.基于可注射生物聚合物的水凝胶：微创治疗的下一代平台。
Gels. 2025 May 23;11(6):383. doi: 10.3390/gels11060383.
7
Structural and Mechanical Characterization of Collagen-Hyaluronan Hydrogels Used to Study Cancer Cell Invasion through the Bladder Wall.用于研究癌细胞通过膀胱壁侵袭的胶原-透明质酸水凝胶的结构与力学特性
ACS Biomater Sci Eng. 2025 Jun 9;11(6):3443-3454. doi: 10.1021/acsbiomaterials.5c00136. Epub 2025 May 15.
8
Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration.用于骨质疏松性骨缺损再生的天然水凝胶支架的创新改性策略及新兴应用
Front Bioeng Biotechnol. 2025 Apr 28;13:1591896. doi: 10.3389/fbioe.2025.1591896. eCollection 2025.
9
Post-Stroke Recovery: A Review of Hydrogel-Based Phytochemical Delivery Systems.中风后恢复：基于水凝胶的植物化学物质递送系统综述
Gels. 2025 Apr 1;11(4):260. doi: 10.3390/gels11040260.
10
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration.一种基于细胞外基质成分的具有生物活性的三层皮肤替代物能有效促进皮肤伤口愈合与再生。
Mater Today Bio. 2025 Feb 20;31:101592. doi: 10.1016/j.mtbio.2025.101592. eCollection 2025 Apr.
本文引用的文献
1
Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology.用于细胞微环境调控的刺激响应性水凝胶：从化学到生物制造技术
Prog Polym Sci. 2019 Nov;98. doi: 10.1016/j.progpolymsci.2019.101147. Epub 2019 Jul 12.
2
Diels-Alder Click-Based Hydrogels for Direct Spatiotemporal Postpatterning via Photoclick Chemistry.基于狄尔斯-阿尔德点击反应的水凝胶，通过光点击化学实现直接时空后图案化
ACS Macro Lett. 2015 Mar 17;4(3):289-292. doi: 10.1021/mz5007427. Epub 2015 Feb 16.
3
Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether.通过将高分子量透明质酸和低分子量透明质酸的混合物与1,4-丁二醇二缩水甘油醚交联来合成透明质酸水凝胶。
RSC Adv. 2020 Feb 18;10(12):7206-7213. doi: 10.1039/c9ra09271d. eCollection 2020 Feb 13.
4
Simultaneous Interpenetrating Polymer Network of Collagen and Hyaluronic Acid as an -Forming Corneal Defect Filler.胶原蛋白和透明质酸同步互穿聚合物网络作为一种用于角膜缺损填充的成型材料
Chem Mater. 2020 Jun 23;32(12):5208-5216. doi: 10.1021/acs.chemmater.0c01307. Epub 2020 May 27.
5
Collagen XV, a multifaceted multiplexin present across tissues and species.胶原蛋白XV，一种存在于各种组织和物种中的多功能多重蛋白聚糖。
Matrix Biol Plus. 2020 Jan 15;6-7:100023. doi: 10.1016/j.mbplus.2020.100023. eCollection 2020 May.
6
Collagen Type I and II Blend Hydrogel with Autologous Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair.I 型和 II 型胶原混合水凝胶与自体间充质干细胞作为关节软骨缺损修复的支架。
ACS Biomater Sci Eng. 2020 Jun 8;6(6):3464-3476. doi: 10.1021/acsbiomaterials.9b01939. Epub 2020 May 27.
7
Particle Hydrogels Based on Hyaluronic Acid Building Blocks.基于透明质酸构建单元的粒子水凝胶
ACS Biomater Sci Eng. 2016 Nov 14;2(11):2034-2041. doi: 10.1021/acsbiomaterials.6b00444. Epub 2016 Sep 27.
8
3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking.具有二次交联的剪切变稀透明质酸水凝胶的3D打印
ACS Biomater Sci Eng. 2016 Oct 10;2(10):1743-1751. doi: 10.1021/acsbiomaterials.6b00158. Epub 2016 Jun 9.
9
Covalently adaptable elastin-like protein - hyaluronic acid (ELP - HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery.具有二级热响应交联的用于可注射干细胞递送的共价适应性弹性蛋白样蛋白 - 透明质酸（ELP - HA）混合水凝胶
Adv Funct Mater. 2017 Jul 26;27(28). doi: 10.1002/adfm.201605609. Epub 2017 May 19.
10
Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum.通过工程化谷氨酸棒杆菌消除胶囊状层以促进透明质酸的产生和葡萄糖摄取。
Nat Commun. 2020 Jun 19;11(1):3120. doi: 10.1038/s41467-020-16962-7.
Zotero 插件