关于降血糖毒素低血糖素和戊-4-烯酸某些药理作用的机制。解决当前困惑的一种方法。 - Suppr

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超能文献

On the mechanisms of some pharmacological actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid. A way out of the present confusion.

作者信息

Stanley H, Sherratt A, Osmundsen H

出版信息

Biochem Pharmacol. 1976 Apr 1;25(7):743-50. doi: 10.1016/0006-2952(76)90139-8.

DOI:10.1016/0006-2952(76)90139-8

PMID:938577

Abstract

摘要

相似文献

On the mechanisms of some pharmacological actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid. A way out of the present confusion.关于降血糖毒素低血糖素和戊-4-烯酸某些药理作用的机制。解决当前困惑的一种方法。

Biochem Pharmacol. 1976 Apr 1;25(7):743-50. doi: 10.1016/0006-2952(76)90139-8.

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。碳水化合物代谢。

Biochem J. 1968 Dec;110(3):521-7. doi: 10.1042/bj1100521.

Biochemical effects of the hypoglycaemic compound pent--4-enoic acid and related non-hypoglycaemic fatty acids.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。

Biochem J. 1968 Dec;110(3):511-9. doi: 10.1042/bj1100511.

Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid. In vitro studies.低血糖素和戊-4-烯酸引起代谢紊乱的机制。体外研究。

Biochem Pharmacol. 1978;27(24):2879-90. doi: 10.1016/0006-2952(78)90204-6.

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。游离酸及其肉碱酯对大鼠肝线粒体中辅酶A依赖性氧化的影响。

Biochem J. 1973 Sep;136(1):157-71. doi: 10.1042/bj1360157.

Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid. In vivo studies.低血糖素和戊-4-烯酸引起代谢紊乱的机制。体内研究。

Biochem Pharmacol. 1978;27(24):2891-900. doi: 10.1016/0006-2952(78)90205-8.

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。丙酮酸、3-羟基丁酸和三羧酸循环中间体的氧化磷酸化及线粒体氧化。

Biochem J. 1968 Dec;110(3):499-509. doi: 10.1042/bj1100499.

The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver.糖异生的调节。戊-4-烯酸对糖异生及离体灌注大鼠肝脏糖异生代谢物浓度的影响。

J Biol Chem. 1970 Feb 25;245(4):818-24.

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of their coenzyme A esters on enzymes of fatty acid oxidation.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化作用。其辅酶A酯对脂肪酸氧化酶的作用。

Biochem J. 1973 Sep;136(1):173-84. doi: 10.1042/bj1360173.

Mechanism of the hypoglycaemia caused by hypoglycin and pent-4-enoate.低血糖素和戊-4-烯酸引起低血糖的机制。

Biochem Soc Trans. 1979 Feb;7(1):106-11. doi: 10.1042/bst0070106.

引用本文的文献

studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.亚甲基环丙基乙酸和亚甲基环丙基甘氨酸引起低血糖的机制研究。

Biochem J. 2018 Mar 20;475(6):1063-1074. doi: 10.1042/BCJ20180063.

Intramitochondrial control of the oxidation of hexadecanoate in skeletal muscle. A study of the acyl-CoA esters which accumulate during rat skeletal-muscle mitochondrial beta-oxidation of [U-14C]hexadecanoate and [U-14C]hexadecanoyl-carnitine.骨骼肌中十六烷酸氧化的线粒体内调控。对在[U-14C]十六烷酸和[U-14C]十六烷酰肉碱的大鼠骨骼肌线粒体β氧化过程中积累的酰基辅酶A酯的研究。

Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):161-8. doi: 10.1042/bj2890161.

Isolated rat heart mitochondria are able to metabolize pent-4-enoate to tricarboxylic acid-cycle intermediates.分离出的大鼠心脏线粒体能够将4-戊烯酸代谢为三羧酸循环中间体。

Biochem J. 1980 Jun 15;188(3):725-9. doi: 10.1042/bj1880725.

2-Mercaptoacetate administration depresses the beta-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity.给予2-巯基乙酸通过抑制长链酰基辅酶A脱氢酶活性来抑制β-氧化途径。

Biochem J. 1981 Jun 15;196(3):803-9. doi: 10.1042/bj1960803.

Effects of 2-mercaptoacetate in isolated liver mitochondria in vitro. Competitive inhibition of 3-hydroxybutyrate dehydrogenase and depression of the beta-oxidation pathway.2-巯基乙酸盐对体外分离的肝线粒体的作用。3-羟基丁酸脱氢酶的竞争性抑制及β-氧化途径的抑制

Biochem J. 1982 Jul 15;206(1):53-9. doi: 10.1042/bj2060053.

Animal models for dicarboxylic aciduria.二羧酸尿症的动物模型

J Inherit Metab Dis. 1984;7 Suppl 1:52-6. doi: 10.1007/BF03047375.

Protection of rats by clofibrate against the hypoglycaemic and toxic effects of hypoglycin and pent-4-enoate. An ultrastructural and biochemical study.氯贝丁酯对大鼠低血糖素和戊-4-烯酸的降血糖及毒性作用的保护作用。一项超微结构和生化研究。

Biochem J. 1985 Jul 15;229(2):387-97. doi: 10.1042/bj2290387.

Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection.骨骼肌线粒体β-氧化。利用连续在线放射化学检测通过高效液相色谱法对[U-14C]十六烷酸氧化产物的研究。

Biochem J. 1988 Jul 15;253(2):541-7. doi: 10.1042/bj2530541.

Valproate-associated hepatotoxicity and its biochemical mechanisms.丙戊酸盐相关的肝毒性及其生化机制。

Med Toxicol Adverse Drug Exp. 1988 Mar-Apr;3(2):85-106. doi: 10.1007/BF03259935.

Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms.邻苯二甲酸二（2-乙基己基）酯（DEHP）导致的过氧化物酶体增殖：物种差异及可能机制。

Environ Health Perspect. 1986 Dec;70:211-9. doi: 10.1289/ehp.8670211.

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